Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Creatine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MVD | P53602 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 14/20 | 0.36 |
| ▸ | CA2 | P00918 | 14/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Creatine SCHEMBL29050789 | 1.00 | MVD (0.41) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL28001981 | 1.00 | MVD (0.41) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL28465232 | 0.98 | MVD (0.40) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL27694435 | 0.98 | MVD (0.40) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL28008273 | 0.98 | MVD (0.40) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL28200258 | 0.98 | MVD (0.40) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL2817384 | 0.98 | MVD (0.42) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL10710660 | 0.98 | MVD (0.42) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL4110519 | 0.98 | MVD (0.42) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL27189 | 0.98 | MVD (0.42) | MVDNOS3NOS1NOS2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 242 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020019938-A1 | COMBINATION PHARMACEUTICAL COMPOSITION FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川九章生物科技有限公司 | 2020-01-30 | — | — | WO | claimed |
| CN-108771668-B | A kind of drug combination composition and its preparation method and application for treating amyotrophic lateral sclerosis | 四川九章生物科技有限公司 | 2019-10-08 | — | — | CN | claimed |
| CN-110294775-A | A kind of purification process of Creatine Phosphate Sodium | 安徽古特生物科技有限公司 | 2019-10-01 | — | — | CN | claimed |
| CN-107383090-B | A kind of synthesis technology of Creatine Phosphate Sodium | 泰山医学院 | 2019-09-17 | — | — | CN | claimed |
| CN-209271383-U | A kind of production Creatine Phosphate Sodium spray drying device | 启东华拓药业有限公司 | 2019-08-20 | — | — | CN | claimed |
| CN-209271456-U | A kind of reaction unit producing Creatine Phosphate Sodium | 启东华拓药业有限公司 | 2019-08-20 | — | — | CN | claimed |
| CN-209161679-U | A kind of Creatine Phosphate Sodium wastewater treatment equipment | 启东华拓药业有限公司 | 2019-07-26 | — | — | CN | claimed |
| CN-109735640-A | The quick detection primer group of mycoplasma pneumoniae, kit | 苏州点晶生物科技有限公司 | 2019-05-10 | — | — | CN | claimed |
| CN-109735660-A | The universal quick detection primer group of Respiratory Syncytial Virus(RSV), kit | 苏州点晶生物科技有限公司 | 2019-05-10 | — | — | CN | claimed |
| CN-109735641-A | A kind of quick detection primer group of chlamydia pneumoniae, kit | 苏州点晶生物科技有限公司 | 2019-05-10 | — | — | CN | claimed |
| CN-101474159-B | Creatine phosphate sodium microballoon lyophilized preparation and method for producing the same | HAINAN MEIDA PHARMACEUTICAL CO | 2010-06-23 | — | — | CN | claimed |
| CN-101732263-A | Creatine phosphate sodium freeze-dried preparation and method for preparing same | YANG JUN | 2010-06-16 | — | — | CN | claimed |
| CN-101716160-A | Creatine phosphate sodium oral solid preparation and preparation method thereof | HARBIN BOLAI PHARMACEUTICAL CO | 2010-06-02 | — | — | CN | claimed |
| CN-101530391-A | Creatine phosphate sodium lipidosome freeze-dried preparation and preparation method thereof | MING WANG | 2009-09-16 | — | — | CN | claimed |
| CN-101474159-A | Creatine phosphate sodium microballoon lyophilized preparation and method for producing the same | HAINAN MEIDA PHARMACEUTICAL CO (CN) | 2009-07-08 | — | — | CN | claimed |
| CN-100493514-C | Composite medicine of creatine phosphate sodium and magnesium salt | XIHONG YANG (CN) | 2009-06-03 | — | — | CN | claimed |
| CN-101313910-A | Preparation technique for sodium phosphocreatine freeze-dried injection | SHANGHAI CRMED SCIENCE CO LTD (CN) | 2008-12-03 | — | — | CN | claimed |
| CN-101288649-A | Preparation technique of sodium phosphocreatine powder and injection preparation | SHANGHAI CIRUI MEDICAL SCI TEC (CN) | 2008-10-22 | — | — | CN | claimed |
| CN-1880954-A | Macro creatine kinase agarose electrophoresis kit and preparation method thereof | UNIV PLA 2ND MILITARY MEDICAL (CN) | 2006-12-20 | — | — | CN | claimed |
| CN-1729988-A | Composite medicine of creatine phosphate sodium and magnesium salt | YANG XIHONG (CN) | 2006-02-08 | — | — | CN | claimed |