Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Creatine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MVD | P53602 | 2/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 14/20 | 0.36 |
| ▸ | CA2 | P00918 | 14/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Creatine SCHEMBL2817384 | 1.00 | MVD (0.42) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL28000876 | 1.00 | MVD (0.42) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL10710660 | 1.00 | MVD (0.42) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL4966668 | 1.00 | MVD (0.42) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL4110519 | 1.00 | MVD (0.42) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL15514026 | 1.00 | MVD (0.42) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL21693685 | 0.98 | MVD (0.41) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL21632997 | 0.98 | MVD (0.41) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL21693673 | 0.98 | MVD (0.41) | MVDNOS3NOS1NOS2CA1 | |
| Creatine SCHEMBL21693688 | 0.98 | MVD (0.45) | MVDNOS3NOS1NOS2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10142 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146272-A1 | ENZYMATIC SYNTHESIS OF MODIFIED NUCLEOSIDE TRIPHOSPHATE ANALOGUES | ILLUMINA, INC. (US) | 2026-05-28 | — | — | US | claimed |
| EP-4747390-A2 | PROTEIN EXPRESSION REAGENTS | Nuclera Ltd (GB) | 2026-05-27 | — | — | EP | claimed |
| CN-121471432-B | Artificial mitochondria nanomotor and preparation method and application thereof | NANJING NORMAL UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| EP-3869192-B1 | METHOD FOR QUANTITATIVE DETECTION OF VARIOUS METABOLITES IN BIOLOGICAL SAMPLE | HUMAN METABOLOMICS INST INC (CN) | 2026-05-13 | — | — | EP | claimed |
| CN-121575166-A | HIV1/2 total nucleic acid detection kit based on isothermal amplification and CRISPR and application thereof | 重庆问创基因科技有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-20260028601-A1 | RECOMBINASE POLYMERASE AMPLIFICATION | ABBOTT DIAGNOSTICS SCARBOROUGH INC (US) | 2026-01-29 | — | — | US | claimed |
| US-20250327108-A1 | Optimized Bioprocessing for Scalable Cell-Free Protein Synthesis | SWIFTSCALE BIOLOGICS INC (US) | 2025-10-23 | — | — | US | claimed |
| EP-4634200-A1 | ENZYMATIC SYNTHESIS OF NTP AND NQP | Codexis, Inc. (US) | 2025-10-22 | — | — | EP | claimed |
| US-20250320540-A1 | Point-of-Care Device for the Determination of Creatine Phosphokinase (CPK) in Biological Samples | IN VITRO DIAGNOSTIC SOLUTIONS (US) | 2025-10-16 | — | — | US | claimed |
| US-20250258146-A1 | QUANTITATIVE DETECTION METHOD OF MULTIPLE METABOLITES IN BIOLOGICAL SAMPLE AND METABOLIC CHIP | HUMAN METABOLOMICS INSTITUTE INC. (CN) | 2025-08-14 | — | — | US | claimed |
| EP-0022432-A1 | Method for determination of creatine kinase | LKB-Produkter AB (SE) | 1981-01-14 | — | — | EP | claimed |
| US-4235961-A | Method for photometric determination of the subunit B of creatine kinase and a reagent for carrying out the method | LKB-PRODUKTER AB (SE) | 1980-11-25 | — | — | US | claimed |
| US-4226935-A | HEXOKINASE AND GLUCOSE-6-PHOSPHATE DEHYDROGENASE BOUND TO CARBOXYLATED POLYETHERURETHANE COPOLYMER | W. R. GRACE & CO. (US) | 1980-10-07 | — | — | US | claimed |
| US-4189536-A | BULKING AGENT OF ALBUMIN, GLYCINE, TAURINE, AND THE TRIS(HYDROXYMETHYL)AMINOMETHANE SALT OF MERCAPTOSUCCINIC ACID, DETERMINATION OF SERUM GLUCOSE AND UREA | HYCEL, INC. (US) | 1980-02-19 | — | — | US | claimed |
| US-4080265-A | Method for the determination of creative phosphokinase enzyme | ANTONIK ALAN S | 1978-03-21 | — | — | US | claimed |
| US-4067775-A | Process and composition for determining the activity of creatinekinase-MB | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1978-01-10 | — | — | US | claimed |
| US-4042462-A | OXIDATION OF NADPH | MONSANTO COMPANY (US) | 1977-08-16 | — | — | US | claimed |
| US-4012286-A | CLINICAL COLORIMETERS | THE DOW CHEMICAL COMPANY (US) | 1977-03-15 | — | — | US | claimed |
| US-4001088-A | LUMINESCENCE, FIREFLY LANTERN EXTRACT, CREATINE PHOSPHATE | ANTONIK ALAN S | 1977-01-04 | — | — | US | claimed |
| US-3956069-A | NICOTINAMIDE-ADENINE DINUCLEOTIDE | ABBOTT LABORATORIES (US) | 1976-05-11 | — | — | US | claimed |