SCHEMBL21634820

SCHEMBL21634820

O=C1O[C@@H](CNc2ccon2)CN1c1ccc(N2CCC3(CC2)CS(=O)(=O)C3)c(F)c1

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAOA P21397 4/20 0.57
CYP2E1 P05181 1/20 0.51
F10 P00742 9/20 0.49
MAOB P27338 9/20 0.48
LMNA P02545 1/20 0.48
PTGS1 P23219 1/20 0.48
CALML3 P27482 1/20 0.48
SDHA P31040 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21634818 0.93 MAOA (0.57) MAOACYP2E1F10MAOBLMNA
SCHEMBL21634822 0.93 MAOA (0.57) MAOACYP2E1F10MAOBLMNA
SCHEMBL21634691 0.90 MAOA (0.55) MAOACYP2E1F10MAOBLMNA
SCHEMBL5833650 0.85 MAOB (0.65) MAOACYP2E1F10MAOBLMNA
SCHEMBL5833644 0.85 MAOB (0.65) MAOACYP2E1F10MAOBLMNA
SCHEMBL6110851 0.85 MAOA (0.62) MAOACYP2E1F10MAOBLMNA
SCHEMBL18409560 0.84 MAOA (0.61) MAOACYP2E1F10MAOBLMNA
SCHEMBL21634693 0.83 MAOA (0.54) MAOACYP2E1F10MAOBLMNA
SCHEMBL30817019 0.82 MAOA (0.59) MAOACYP2E1F10MAOBLMNA
SCHEMBL30817028 0.82 MAOA (0.59) MAOACYP2E1F10MAOBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12109203-B2 Substituted oxazolidinones for the treatment of mammalian infections ZYDUS LIFESCIENCES LIMITED (IN) 2024-10-08 US claimed
WO-2020021468-A1 SUBSTITUTED OXAZOLIDINONES FOR THE TREATMENT OF MAMMALIAN INFECTIONS CADILA HEALTHCARE LIMITED (IN) 2020-01-30 WO claimed
US-12109203-B2 Substituted oxazolidinones for the treatment of mammalian infections ZYDUS LIFESCIENCES LIMITED (IN) 2024-10-08 US disclosed
WO-2020021468-A1 SUBSTITUTED OXAZOLIDINONES FOR THE TREATMENT OF MAMMALIAN INFECTIONS CADILA HEALTHCARE LIMITED (IN) 2020-01-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12109203-B2 Substituted oxazolidinones for the treatment of mammalian infections OXA1L, IL4I1, PEPD MAOA 2648/4885CYP2E1 273/4885F10 4371/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.