Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21637233 | 0.87 | HTT (0.46) | HTTSMN1; SMN2IRAK4HSD17B10TDP1 | |
| SCHEMBL14881882 | 0.84 | IRAK4 (0.49) | SMN1; SMN2IRAK4NPC1RAB9AKMT2A | |
| SCHEMBL21765953 | 0.83 | IRAK4 (0.50) | HTTSMN1; SMN2IRAK4HSD17B10TDP1 | |
| SCHEMBL14881490 | 0.81 | IRAK4 (0.47) | IRAK4DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL14881458 | 0.81 | IRAK4 (0.47) | IRAK4DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL21637248 | 0.81 | HTT (0.46) | HTTSMN1; SMN2IRAK4HSD17B10TDP1 | |
| SCHEMBL21637228 | 0.80 | NPC1 (0.58) | HTTSMN1; SMN2IRAK4NPC1RAB9A | |
| SCHEMBL16243677 | 0.78 | NTRK1 (0.46) | IRAK4 | |
| SCHEMBL16243675 | 0.78 | NTRK1 (0.46) | IRAK4 | |
| SCHEMBL21765821 | 0.78 | IRAK4 (0.48) | IRAK4TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840832-B1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2023-10-11 | — | — | EP | disclosed |
| WO-2021148805-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BENEVOLENTAI BIO LIMITED (GB) | 2021-07-29 | — | — | WO | disclosed |
| WO-2020039209-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-02-27 | — | — | WO | disclosed |
| WO-2020016594-A1 | IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-01-23 | — | — | WO | disclosed |