Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 13/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21765953 | 0.81 | IRAK4 (0.50) | IRAK4TGFBR1 | |
| SCHEMBL21637243 | 0.78 | HTT (0.47) | IRAK4TGFBR1 | |
| SCHEMBL21637233 | 0.76 | HTT (0.46) | IRAK4TGFBR1 | |
| SCHEMBL21637236 | 0.76 | IRAK4 (0.48) | IRAK4TGFBR1NTRK1 | |
| SCHEMBL21765957 | 0.75 | NTRK1 (0.40) | IRAK4TGFBR1NTRK1HPGDS | |
| SCHEMBL18654864 | 0.74 | IRAK4 (0.47) | IRAK4 | |
| SCHEMBL30032981 | 0.73 | NTRK1 (0.57) | NTRK1 | |
| SCHEMBL20355593 | 0.73 | IRAK4 (0.53) | IRAK4 | |
| SCHEMBL14897258 | 0.73 | IRAK4 (0.48) | IRAK4NTRK1 | |
| SCHEMBL14897731 | 0.73 | IRAK4 (0.46) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840832-B1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2023-10-11 | — | — | EP | disclosed |
| WO-2021148805-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BENEVOLENTAI BIO LIMITED (GB) | 2021-07-29 | — | — | WO | disclosed |
| WO-2020039209-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-02-27 | — | — | WO | disclosed |