Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | CASP1 | P29466 | 3/20 | 0.41 |
| ▸ | CASP7 | P55210 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21637243 | 0.83 | HTT (0.47) | IRAK4HTTSMN1; SMN2TGFBR1NPC1 | |
| SCHEMBL19467090 | 0.83 | NPSR1 (0.54) | IRAK4HTTSMN1; SMN2TGFBR1LMNA | |
| SCHEMBL21637233 | 0.82 | HTT (0.46) | IRAK4HTTSMN1; SMN2TGFBR1HSD17B10 | |
| SCHEMBL19466993 | 0.82 | IRAK4 (0.45) | IRAK4CREBBPTGFBR1NPSR1 | |
| SCHEMBL21765821 | 0.81 | IRAK4 (0.48) | IRAK4TGFBR1 | |
| SCHEMBL20355593 | 0.79 | IRAK4 (0.53) | IRAK4HTTSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL14897368 | 0.79 | IRAK4 (0.46) | IRAK4SMN1; SMN2LMNANPC1ALDH1A1 | |
| SCHEMBL14897258 | 0.79 | IRAK4 (0.48) | IRAK4SMN1; SMN2HSD17B10ALDH1A1MAPT | |
| SCHEMBL14897731 | 0.79 | IRAK4 (0.46) | IRAK4HTTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL18654705 | 0.79 | IRAK4 (0.43) | IRAK4CREBBPHTTSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840832-B1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2023-10-11 | — | — | EP | disclosed |
| WO-2021148805-A1 | TOPICAL PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZO[1,2-B]PYRIDAZINE COMPOUNDS | BENEVOLENTAI BIO LIMITED (GB) | 2021-07-29 | — | — | WO | disclosed |
| WO-2020039209-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-02-27 | — | — | WO | disclosed |