Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483403 | 0.81 | CYP3A4 (0.48) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL2163741 | 0.76 | PAX8 (0.58) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL484152 | 0.76 | CYP3A4 (0.54) | KDM4ELMNASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL2163767 | 0.75 | NPC1 (0.47) | KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL12467969 | 0.74 | CYP19A1 (0.47) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL20707610 | 0.72 | ACHE (0.61) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL483736 | 0.69 | ACHE (0.57) | DHODHKDM4ELMNASMN1; SMN2PDE10A | |
| SCHEMBL2162654 | 0.68 | ACP1 (0.50) | KDM4ELMNASMN1; SMN2PDE10AALDH1A1 | |
| SCHEMBL28266149 | 0.68 | KDM4E (0.71) | KDM4ELMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL15602868 | 0.68 | APP (0.57) | KDM4ESMN1; SMN2ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130302248-A1 | Imaging Agents for Detecting Neurological Disorders | LILLY CO ELI (US) | 2013-11-14 | — | — | US | disclosed |
| US-20110182812-A1 | Imaging Agents for Detecting Neurological Disorders | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130302248-A1 | Imaging Agents for Detecting Neurological Disorders | MAPT, APP, PSEN1 | DHODH 4030/4885KDM4E 4835/4885LMNA 991/4885 |
| US-20110182812-A1 | Imaging Agents for Detecting Neurological Disorders | MAPT, APP, PSEN1 | DHODH 4437/4885KDM4E 4835/4885LMNA 569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.