Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 15/20 | 0.84 |
| ▸ | DPP7 | Q9UHL4 | 10/20 | 0.84 |
| ▸ | DPP8 | Q6V1X1 | 8/20 | 0.84 |
| ▸ | DPP9 | Q86TI2 | 7/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL29353244 | 1.00 | DPP4 (0.84) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL353709 | 0.92 | DPP4 (1.00) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL12291433 | 0.92 | DPP4 (1.00) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL846295 | 0.92 | DPP4 (1.00) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL392505 | 0.92 | DPP4 (1.00) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL356202 | 0.92 | DPP4 (1.00) | DPP4DPP7DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL5708932 | 0.90 | DPP4 (0.97) | DPP4DPP7DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL5708931 | 0.90 | DPP4 (0.97) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL28071366 | 0.82 | DPP4 (0.82) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL28071368 | 0.82 | DPP4 (0.82) | DPP4DPP7DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3199203-B1 | SUBSTITUTED XANTHINE DERIVATIVES | CONCERT PHARMACEUTICALS INC (US) | 2020-02-05 | — | — | EP | claimed |