SCHEMBL356202

SCHEMBL356202

CCC(C)C(N)C(=O)N1CCSC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 15/20 1.00
DPP7 Q9UHL4 10/20 1.00
DPP8 Q6V1X1 8/20 1.00
DPP9 Q86TI2 7/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL353709 1.00 DPP4 (1.00) DPP4DPP7DPP8DPP9
SCHEMBL392505 1.00 DPP4 (1.00) DPP4DPP7DPP8DPP9
SCHEMBL12291433 1.00 DPP4 (1.00) DPP4DPP7DPP8DPP9
SCHEMBL846295 1.00 DPP4 (1.00) DPP4DPP7DPP8DPP9
Hydrochloric Acid SCHEMBL5708932 0.98 DPP4 (0.97) DPP4DPP7DPP8DPP9
Hydrochloric Acid SCHEMBL5708931 0.98 DPP4 (0.97) DPP4DPP7DPP8DPP9
Fumaric Acid SCHEMBL29353244 0.92 DPP4 (0.84) DPP4DPP7DPP8DPP9
Fumaric Acid SCHEMBL21638348 0.92 DPP4 (0.84) DPP4DPP7DPP8DPP9
SCHEMBL28071368 0.90 DPP4 (0.82) DPP4DPP7DPP8DPP9
SCHEMBL28071366 0.90 DPP4 (0.82) DPP4DPP7DPP8DPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240115577-A1 SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES THE SCRIPPS RESEARCH INSTITUTE 2024-04-11 US claimed
EP-3199203-B1 SUBSTITUTED XANTHINE DERIVATIVES CONCERT PHARMACEUTICALS INC (US) 2020-02-05 EP claimed
US-20240115577-A1 SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES THE SCRIPPS RESEARCH INSTITUTE 2024-04-11 US disclosed
EP-3199203-B1 SUBSTITUTED XANTHINE DERIVATIVES CONCERT PHARMACEUTICALS INC (US) 2020-02-05 EP disclosed
US-20140142145-A1 COMBINATIONS COMPRISING A DIPEPTIDYLPEPTIDASE - IV INHIBITOR BALKAN BORK (US) 2014-05-22 US disclosed
US-20140142145-A1 COMBINATIONS COMPRISING A DIPEPTIDYLPEPTIDASE - IV INHIBITOR BALKAN BORK (US) 2014-05-22 US disclosed
US-20120015029-A1 DIRECT COMPRESSION FORMULATION AND PROCESS PFEFFER SABINE (DE) 2012-01-19 US disclosed
EP-1658066-B9 ADAMANTYLGLYCINE- BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV FOR THE TREATMENT OF DIABETES BRISTOL MYERS SQUIBB CO (US) 2010-02-24 EP disclosed
EP-1658066-B1 ADAMANTYLGLYCINE- BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV FOR THE TREATMENT OF DIABETES BRISTOL MYERS SQUIBB CO (US) 2009-09-30 EP disclosed
US-20080300293-A1 COMBINATION OF AN DPP-IV INHIBITOR AND A PPAR-ALPHA COMPOUND WANG PEI-RAN 2008-12-04 US disclosed
US-20080300293-A1 COMBINATION OF AN DPP-IV INHIBITOR AND A PPAR-ALPHA COMPOUND WANG PEI-RAN 2008-12-04 US disclosed
US-20080076811-A1 COMBINATIONS COMPRISING DEPEPTIDYPEPTIDASE-IV INHIBITORS AND ANTIDIABETIC AGENTS BALKAN BORK 2008-03-27 US disclosed
US-20080076811-A1 COMBINATIONS COMPRISING DEPEPTIDYPEPTIDASE-IV INHIBITORS AND ANTIDIABETIC AGENTS BALKAN BORK 2008-03-27 US disclosed
CN-101115740-A Treatment of substituted pyridyl and pyrimidinyl derivatives and related diseases as metabolic modulators ARENA PHARM INC (US) 2008-01-30 CN disclosed
EP-1743655-A1 Combinations comprising dipeptidylpeptidase-IV inhibitors and antidiabetic agents Novartis AG (CH) 2007-01-17 EP disclosed
EP-1741447-A2 Combinations comprising dipeptidylpeptidase-IV inhibitors and antidiabetic agents Novartis AG (CH) 2007-01-10 EP disclosed
EP-1741445-A2 Combinations comprising dipeptidylpeptidase-IV inhibitors and antidiabetic agents Novartis AG (CH) 2007-01-10 EP disclosed
EP-1741446-A2 Combinations comprising dipeptidylpeptidase-IV inhibitors and antidiabetic agents Novartis AG (CH) 2007-01-10 EP disclosed
WO-2005012249-A2 ADAMANTYGLYCINE- BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV FOR THE TREATMENT OF DIABETES BRISTOL-MYERS SQUIBB COMPANY (US) 2005-02-10 WO disclosed
WO-2004052362-A1 COMBINATION OF AN DPP-IV INHIBITOR AND A PPAR-ALPHA COMPOUND NOVARTIS AG (CH) 2004-06-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080076811-A1 COMBINATIONS COMPRISING DEPEPTIDYPEPTIDASE-IV INHIBITORS AND ANTIDIABETIC AGENTS G6PC1, GCK, PDK4 DPP4 17/4885DPP7 28/4885DPP8 36/4885
US-20120015029-A1 DIRECT COMPRESSION FORMULATION AND PROCESS DPP4, DPP3, DPP7 DPP4 1/4885DPP7 3/4885DPP8 6/4885
US-20080300293-A1 COMBINATION OF AN DPP-IV INHIBITOR AND A PPAR-ALPHA COMPOUND PPARG, DPP4, FABP4 DPP4 2/4885DPP7 18/4885DPP8 17/4885
US-20140142145-A1 COMBINATIONS COMPRISING A DIPEPTIDYLPEPTIDASE - IV INHIBITOR DPP4, DPP7, DPP3 DPP4 1/4885DPP7 2/4885DPP8 4/4885
US-20240115577-A1 SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES DPP4, DPP7, ING2 DPP4 1/4885DPP7 2/4885DPP8 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.