Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.46 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16722665 | 0.90 | BRD4 (0.46) | BRD4KDM5AALDH1A1USP30JAK2 | |
| SCHEMBL21638456 | 0.90 | BRD4 (0.49) | BRD4NAMPT | |
| SCHEMBL21638680 | 0.89 | BRD4 (0.48) | BRD4NAMPT | |
| SCHEMBL16721741 | 0.89 | BRD4 (0.54) | BRD4KDM5AALDH1A1JAK2TYK2 | |
| SCHEMBL16722352 | 0.89 | BRD4 (0.54) | BRD4KDM5AALDH1A1JAK2TYK2 | |
| SCHEMBL21638712 | 0.87 | BRD4 (0.47) | BRD4NAMPTUSP30CTSKCTSC | |
| SCHEMBL21638620 | 0.86 | BRD4 (0.46) | BRD4NAMPT | |
| SCHEMBL21638725 | 0.86 | BRD4 (0.45) | BRD4NAMPT | |
| SCHEMBL21638495 | 0.85 | BRD4 (0.41) | BRD4ALDH1A1USP30JAK2TYK2 | |
| SCHEMBL21638678 | 0.85 | BRD4 (0.48) | BRD4NAMPTCTSKCTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071205-B1 | BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS | FORMA THERAPEUTICS INC (US) | 2020-02-05 | — | — | EP | claimed |