Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | SIK1 | P57059 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.38 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | LIPC | P11150 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21638456 | 0.90 | BRD4 (0.49) | BRD4IDH1KITNAMPT | |
| SCHEMBL16722502 | 0.90 | BRD4 (0.47) | BRD4USP30IDH1PRKAB2ABL1 | |
| SCHEMBL21638680 | 0.90 | BRD4 (0.48) | BRD4IDH1NAMPT | |
| SCHEMBL16722032 | 0.88 | BRD4 (0.55) | BRD4USP30IDH1PRKAB2ABL1 | |
| SCHEMBL21638490 | 0.87 | BRD4 (0.46) | BRD4USP30NAMPTCTSKCTSC | |
| SCHEMBL21638620 | 0.87 | BRD4 (0.46) | BRD4LIPCLIPGNAMPT | |
| SCHEMBL16721523 | 0.87 | BRD4 (0.53) | BRD4USP30IDH1PRKAB2ABL1 | |
| SCHEMBL21638725 | 0.86 | BRD4 (0.45) | BRD4IDH1NAMPT | |
| SCHEMBL21638678 | 0.86 | BRD4 (0.48) | BRD4IDH1NAMPTTBK1CTSK | |
| SCHEMBL21638695 | 0.85 | BRD4 (0.47) | BRD4NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071205-B1 | BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS | FORMA THERAPEUTICS INC (US) | 2020-02-05 | — | — | EP | disclosed |