SCHEMBL2164185

SCHEMBL2164185

N#CC(O)c1ccc(Br)cc1

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.60
CYP2A6 P11509 1/20 0.38
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
CYP1A2 P05177 1/20 0.38
ALOX5 P09917 1/20 0.37
KDM4E B2RXH2 1/20 0.37
RECQL P46063 1/20 0.36
ALOX15 P16050 1/20 0.36
CFTR P13569 1/20 0.36
CTSK P43235 2/20 0.35
HTR2A P28223 1/20 0.34
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
NAAA Q02083 1/20 0.33
CYP2C19 P33261 1/20 0.33
TRPA1 O75762 1/20 0.33
CNR1 P21554 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6689869 1.00 TSHR (0.60) TSHRCYP2A6ESR1ESR2CYP1A2
SCHEMBL27646186 1.00 TSHR (0.60) TSHRCYP2A6ESR1ESR2CYP1A2
SCHEMBL4319988 0.78 ESR1 (0.62) TSHRESR1ESR2CYP1A2KDM4E
SCHEMBL7262475 0.78 ESR1 (0.62) TSHRESR1ESR2CYP1A2KDM4E
SCHEMBL467691 0.78 ESR1 (0.62) TSHRESR1ESR2CYP1A2KDM4E
SCHEMBL199580 0.76 TSHR (0.60) TSHRESR1ESR2ALOX5KDM4E
SCHEMBL6908022 0.76 TSHR (0.60) TSHRESR1ESR2ALOX5KDM4E
SCHEMBL7865922 0.76 TSHR (0.60) TSHRCYP2A6ESR1ESR2ALOX5
SCHEMBL8020863 0.76 TSHR (0.60) TSHRESR1ESR2CYP1A2ALOX15
SCHEMBL8019231 0.76 TSHR (0.60) TSHRESR1ESR2ALOX5KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103396341-A Synthesis method of chiral hydroxy nitrile LUO MEI 2013-11-20 CN claimed
US-7985572-B2 Modified nitrilases and their use in methods for the production of carboxylic acids BASF SE (DE) 2011-07-26 US claimed
EP-1599584-B1 MODIFIED NITRILASES AND THEIR USE IN METHODS FOR THE PRODUCTION OF CARBOXYLIC ACIDS BASF SE (DE) 2009-07-01 EP claimed
US-20060259999-A1 Modified nitrilases and their use in methods for the production of carboxylic acids BASF AKTIENGESELLSCHAFT (DE) 2006-11-16 US claimed
EP-2403842-B1 CHIRAL DISULFONIMIDES STUDIENGESELLSCHAFT KOHLE MBH (DE) 2016-06-29 EP disclosed
US-9315792-B2 Nitrilases, nucleic acids encoding them and methods for making and using them BASF ENZYMES LLC (US) 2016-04-19 US disclosed
US-9217164-B2 Nitrilases, nucleic acids encoding them and methods for making and using them BASF ENZYMES LLC (US) 2015-12-22 US disclosed
EP-2327766-B1 Nitrilases BASF ENZYMES LLC (US) 2015-12-02 EP disclosed
EP-2319919-B1 Nitrilases BASF ENZYMES LLC (US) 2015-08-12 EP disclosed
US-9079869-B2 Chiral disulfonimides STUDIENGESELLSCHAFT KOHLE MBH (DE) 2015-07-14 US disclosed
US-9079869-B2 Chiral disulfonimides STUDIENGESELLSCHAFT KOHLE MBH (DE) 2015-07-14 US disclosed
EP-1576108-B1 NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM BASF ENZYMES LLC (US) 2015-07-08 EP disclosed
CN-1305482-A Artemisinin derivatives, method for preparation thereof and pharmaceutical compositions containing the same SHANGHAI INST OF MATERIAL MEDI (CN) 2001-07-25 CN disclosed
EP-1086107-A1 ARTEMISININ DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) 2001-03-28 EP disclosed
EP-0711836-B1 Method of producing optically active alpha-hydroxy acid or alpha-hydroxyamide MITSUBISHI RAYON CO (JP) 2000-02-02 EP disclosed
WO-1999065914-A1 ARTEMISININ DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME SHANGHAI INSTITUTE OF MATERIA MEDICA (CN) 1999-12-23 WO disclosed
CN-1239097-A Artemisine compounds, their preparing process and medicine composition containing them SHANGHAI INST OF MEDICINAL MAT (CN) 1999-12-22 CN disclosed
US-5736385-A NITRILASE OR NITRILE HYDRATASE HYDROLYSIS OF A CYANOHYDRIN WHILE AUTOMATICALLY CONTROLLING CYANOHYDRIN CONCENTRATION NITTO CHEMICAL INDUSTRY CO., LTD. (JP) 1998-04-07 US disclosed
EP-0711836-A1 Method of producing optically active alpha-hydroxy acid or alpha-hydroxyamide NITTO CHEMICAL INDUSTRY CO., LTD. (JP) 1996-05-15 EP disclosed
US-3976638-A STEROID, ANTIINFLAMMATORY E. R. SQUIBB & SONS, INC. (US) 1976-08-24 US disclosed