Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2779187 | 0.93 | SIGMAR1 (0.45) | SIGMAR1IDO1NQO2CTSKCTSS | |
| SCHEMBL2168456 | 0.90 | NR1H4 (0.44) | SIGMAR1IDO1NQO2CTSSNPSR1 | |
| SCHEMBL2151042 | 0.88 | SIGMAR1 (0.48) | SIGMAR1IDO1CTSKNPSR1POLB | |
| SCHEMBL2164881 | 0.86 | NR1H4 (0.45) | SIGMAR1IDO1CTSSNR1H4TMEM97 | |
| SCHEMBL3138728 | 0.79 | L3MBTL1 (0.48) | SIGMAR1IDO1CTSSNPSR1NR1H4 | |
| SCHEMBL3134720 | 0.79 | EPHX1 (0.39) | NQO2KDM4ENR1H4 | |
| SCHEMBL2164212 | 0.78 | ACE (0.42) | SIGMAR1IDO1CTSKCTSSTMEM97 | |
| SCHEMBL3135260 | 0.77 | HDAC1 (0.37) | SIGMAR1IDO1POLBKDM4ENR1H4 | |
| SCHEMBL942893 | 0.77 | IDO1 (0.51) | SIGMAR1IDO1KDM4ECKS1BSKP1 | |
| SCHEMBL2150723 | 0.76 | ACACB (0.40) | SIGMAR1NQO2KDM4ENR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340242-A2 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-06 | — | — | EP | disclosed |