Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21642985 | 1.00 | SCN9A (0.37) | SCN9AMAPTALDH1A1KDM4EGLA | |
| SCHEMBL20289650 | 0.90 | TSHR (0.31) | TSHR | |
| SCHEMBL21857661 | 0.89 | SCN9A (0.34) | SCN9AMAPTALDH1A1KDM4EGLA | |
| SCHEMBL21857662 | 0.89 | SCN9A (0.34) | SCN9AMAPTALDH1A1KDM4EGLA | |
| SCHEMBL21953200 | 0.89 | SCN9A (0.34) | SCN9AMAPTALDH1A1KDM4EGLA | |
| SCHEMBL30066002 | 0.89 | SCN9A (0.34) | SCN9AMAPTALDH1A1KDM4EGLA | |
| SCHEMBL19011559 | 0.87 | SCN9A (0.43) | SCN9AMAPTALDH1A1KDM4EGLA | |
| SCHEMBL22712643 | 0.87 | SCN9A (0.43) | SCN9AMAPTALDH1A1KDM4EGLA | |
| SCHEMBL15303825 | 0.87 | HDAC4 (0.36) | SCN9AMAPTALDH1A1KDM4EGLA | |
| SCHEMBL16200798 | 0.87 | HDAC4 (0.36) | SCN9AMAPTALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390394-B1 | HYDANTOIN MODULATORS OF KV3 CHANNELS | AUTIFONY THERAPEUTICS LTD (GB) | 2022-05-25 | — | — | EP | disclosed |
| US-20200377485-A1 | HYDANTOIN MODULATORS OF KV3 CHANNELS | AUTIFONY THERAPEUTICS LTD (GB) | 2020-12-03 | — | — | US | disclosed |
| US-20200039970-A1 | HYDANTOIN MODULATORS OF KV3 CHANNELS | AUTIFONY SRL (IT) | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377485-A1 | HYDANTOIN MODULATORS OF KV3 CHANNELS | KCNA3, KCNN3, KCND3 | SCN9A 100/4885MAPT 3209/4885ALDH1A1 2103/4885 |
| US-20200039970-A1 | HYDANTOIN MODULATORS OF KV3 CHANNELS | KCNA3, KCNQ3, KCNN3 | SCN9A 127/4885MAPT 4092/4885ALDH1A1 2319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.