Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19011559 | 1.00 | SCN9A (0.43) | SCN9AIDO1TDO2MAPTHDAC8 | |
| SCHEMBL21953273 | 0.89 | SCN9A (0.40) | SCN9AIDO1TDO2MAPTHDAC8 | |
| SCHEMBL31009066 | 0.89 | SCN9A (0.40) | SCN9AIDO1TDO2MAPTHDAC8 | |
| SCHEMBL21642985 | 0.87 | SCN9A (0.37) | SCN9AIDO1TDO2MAPTHDAC8 | |
| SCHEMBL21642986 | 0.87 | SCN9A (0.37) | SCN9AIDO1TDO2MAPTHDAC8 | |
| SCHEMBL29438022 | 0.85 | CA12 (0.39) | SCN9AHDAC8HDAC4HDAC1HDAC3 | |
| SCHEMBL9923816 | 0.85 | CA12 (0.39) | SCN9AHDAC8HDAC4HDAC1HDAC3 | |
| SCHEMBL22712639 | 0.83 | IDO1 (0.37) | SCN9AIDO1TDO2MAPTALDH1A1 | |
| SCHEMBL19011497 | 0.83 | IDO1 (0.37) | SCN9AIDO1TDO2MAPTALDH1A1 | |
| SCHEMBL23750239 | 0.80 | SCN9A (0.39) | SCN9AMAPTHDAC8HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390394-B1 | HYDANTOIN MODULATORS OF KV3 CHANNELS | AUTIFONY THERAPEUTICS LTD (GB) | 2022-05-25 | — | — | EP | disclosed |
| US-20200377485-A1 | HYDANTOIN MODULATORS OF KV3 CHANNELS | AUTIFONY THERAPEUTICS LTD (GB) | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377485-A1 | HYDANTOIN MODULATORS OF KV3 CHANNELS | KCNA3, KCNN3, KCND3 | SCN9A 100/4885IDO1 1238/4885TDO2 1442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.