Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 7/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.38 |
| ▸ | PTGFR | P43088 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.37 |
| ▸ | PTGIR | P43119 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14148738 | 0.81 | EGFR (0.69) | EGFRNPSR1MIFMETAP2PTGER3 | |
| SCHEMBL8125134 | 0.80 | EGFR (0.50) | EGFRNPSR1MIFMETAP2PTGER3 | |
| SCHEMBL8125136 | 0.80 | EGFR (0.50) | EGFRNPSR1MIFMETAP2PTGER3 | |
| SCHEMBL3708005 | 0.77 | ALDH1A1 (0.50) | NPSR1MIFCA1CA2NFKB1 | |
| SCHEMBL3708007 | 0.77 | ALDH1A1 (0.50) | NPSR1MIFCA1CA2NFKB1 | |
| SCHEMBL18046005 | 0.76 | TDO2 (0.55) | EGFRNPSR1MIFMETAP2CA1 | |
| SCHEMBL15866178 | 0.76 | TDO2 (0.55) | EGFRNPSR1MIFMETAP2CA1 | |
| SCHEMBL21643613 | 0.75 | MIF (0.38) | EGFRNPSR1MIFMETAP2PTGER3 | |
| SCHEMBL27616680 | 0.74 | HCAR2 (0.53) | ESR1CA1CA2NFKB1CA4 | |
| SCHEMBL27616679 | 0.74 | HCAR2 (0.53) | ESR1CA1CA2NFKB1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200039972-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | IMAGO PHARMACEUTICALS, INC. (US) | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200039972-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | CHUK, MAPK6, MAPK3 | EGFR 438/4885NPSR1 3659/4885MIF 4303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.