Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29436967 | 1.00 | STING1 (0.39) | STING1BRD4HDAC1CA1CA2 | |
| SCHEMBL21158085 | 0.89 | SERPINE1 (0.39) | STING1BRD4HDAC1CA1CA2 | |
| SCHEMBL20889072 | 0.87 | STING1 (0.45) | STING1KDM4ELMNAGAAALDH1A1 | |
| SCHEMBL29012734 | 0.87 | STING1 (0.45) | STING1KDM4ELMNAGAAALDH1A1 | |
| SCHEMBL29406354 | 0.87 | STING1 (0.45) | STING1KDM4ELMNAGAAALDH1A1 | |
| SCHEMBL21643823 | 0.84 | MAPT (0.32) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL21643820 | 0.84 | MAPT (0.32) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL29436946 | 0.84 | SMN1; SMN2 (0.38) | STING1LMNAMEN1GAAKMT2A | |
| SCHEMBL21643850 | 0.84 | SMN1; SMN2 (0.38) | STING1LMNAMEN1GAAKMT2A | |
| SCHEMBL22121412 | 0.82 | STING1 (0.38) | STING1BRD4HDAC1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230398225-A1 | PD-L1/STING CONJUGATES AND METHODS OF USE | INCYTE CORPORATION | 2023-12-14 | — | — | US | disclosed |
| US-20230398225-A1 | PD-L1/STING CONJUGATES AND METHODS OF USE | INCYTE CORPORATION | 2023-12-14 | — | — | US | disclosed |
| US-20230398225-A1 | PD-L1/STING CONJUGATES AND METHODS OF USE | INCYTE CORPORATION | 2023-12-14 | — | — | US | disclosed |
| US-11713317-B2 | Tricyclic heterocyclic compounds as sting activators | INCYTE CORPORATION (US) | 2023-08-01 | — | — | US | disclosed |
| US-11713317-B2 | Tricyclic heterocyclic compounds as sting activators | INCYTE CORPORATION (US) | 2023-08-01 | — | — | US | disclosed |
| US-11713317-B2 | Tricyclic heterocyclic compounds as sting activators | INCYTE CORPORATION (US) | 2023-08-01 | — | — | US | disclosed |
| US-11596692-B1 | PD-L1/STING conjugates and methods of use | INCYTE CORPORATION (US) | 2023-03-07 | — | — | US | disclosed |
| US-11596692-B1 | PD-L1/STING conjugates and methods of use | INCYTE CORPORATION (US) | 2023-03-07 | — | — | US | disclosed |
| US-11427597-B2 | Heteroaryl amide compounds as sting activators | INCYTE CORPORATION (US) | 2022-08-30 | — | — | US | disclosed |
| EP-3802534-B1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS STING ACTIVATORS | INCYTE CORP (US) | 2022-07-13 | — | — | EP | disclosed |
| US-10947227-B2 | Tricyclic heterocyclic compounds as sting activators | INCYTE CORPORATION (US) | 2021-03-16 | — | — | US | disclosed |
| US-10947227-B2 | Tricyclic heterocyclic compounds as sting activators | INCYTE CORPORATION (US) | 2021-03-16 | — | — | US | disclosed |
| US-10875872-B2 | Heteroaryl amide compounds as sting activators | INCYTE CORPORATION (US) | 2020-12-29 | — | — | US | disclosed |
| US-10875872-B2 | Heteroaryl amide compounds as sting activators | INCYTE CORPORATION (US) | 2020-12-29 | — | — | US | disclosed |
| WO-2020132582-A1 | STING AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020132566-A1 | STING PYRAZOLE AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020028566-A1 | HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS | INCYTE CORPORATION (US) | 2020-02-06 | — | — | WO | disclosed |
| WO-2020028566-A1 | HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS | INCYTE CORPORATION (US) | 2020-02-06 | — | — | WO | disclosed |
| US-20200039994-A1 | HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS | INCYTE CORPORATION | 2020-02-06 | — | — | US | disclosed |
| US-20200039994-A1 | HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS | INCYTE CORPORATION | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11596692-B1 | PD-L1/STING conjugates and methods of use | STING1, PDCD1LG2, CD274 | STING1 1/4885BRD4 636/4885HDAC1 3667/4885 |
| US-20230398225-A1 | PD-L1/STING CONJUGATES AND METHODS OF USE | STING1, PDCD1LG2, CD274 | STING1 1/4885BRD4 636/4885HDAC1 3667/4885 |
| US-11713317-B2 | Tricyclic heterocyclic compounds as sting activators | STING1, MAVS, IRF3 | STING1 1/4885BRD4 398/4885HDAC1 3066/4885 |
| US-10875872-B2 | Heteroaryl amide compounds as sting activators | STING1, MAVS, IRF3 | STING1 1/4885BRD4 286/4885HDAC1 2944/4885 |
| US-10947227-B2 | Tricyclic heterocyclic compounds as sting activators | STING1, MAVS, IRF3 | STING1 1/4885BRD4 398/4885HDAC1 3066/4885 |
| US-11427597-B2 | Heteroaryl amide compounds as sting activators | STING1, MAVS, IRF3 | STING1 1/4885BRD4 286/4885HDAC1 2944/4885 |
| US-20200039994-A1 | HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS | STING1, MAVS, IRF3 | STING1 1/4885BRD4 286/4885HDAC1 2944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.