Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.56 |
| ▸ | BCL2 | P10415 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 7/20 | 0.49 |
| ▸ | JAK2 | O60674 | 5/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21644634 | 0.85 | BCL2 (0.69) | NPC1RAB9ABCL2KDM4EHTT | |
| SCHEMBL21644571 | 0.84 | KCNMA1 (0.60) | NPC1RAB9AKCNMA1BCL2KDM4E | |
| SCHEMBL21644546 | 0.83 | P2RX1 (0.56) | NPC1RAB9ABCL2KDM4EHTT | |
| SCHEMBL21644609 | 0.77 | SMN1; SMN2 (0.54) | NPC1RAB9ABCL2HTT | |
| SCHEMBL21644596 | 0.76 | NPC1 (0.58) | NPC1RAB9AHTT | |
| SCHEMBL30474350 | 0.75 | HSP90AA1 (0.56) | BCL2 | |
| SCHEMBL21644578 | 0.75 | ALDH1A1 (0.59) | NPC1RAB9AHTT | |
| SCHEMBL21644539 | 0.75 | TMPRSS4 (0.63) | NPC1RAB9AKDM4EL3MBTL1 | |
| SCHEMBL15478027 | 0.75 | NPC1 (1.00) | NPC1RAB9AKCNMA1KDM4E | |
| SCHEMBL28421724 | 0.74 | TYK2 (0.56) | TYK2JAK2JAK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111164074-B | Heat shock protein 90 inhibitors | 台北医学大学 | 2024-02-02 | — | — | CN | disclosed |
| US-11479528-B2 | Heat shock protein 90 inhibitors | TAIPEI MEDICAL UNIVERSITY (TW) | 2022-10-25 | — | — | US | disclosed |
| CN-111164074-A | Heat shock protein 90 inhibitor | 台北医学大学 | 2020-05-15 | — | — | CN | disclosed |
| US-20200039923-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | TAIPEI MEDICAL UNIVERSITY (TW) | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200039923-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | HSP90AB1, HSP90AB2P, HSP90AA1 | NPC1 1353/4885RAB9A 1972/4885KCNMA1 4571/4885 |
| US-11479528-B2 | Heat shock protein 90 inhibitors | HSP90AB1, HSP90AB2P, HSP90AA1 | NPC1 1353/4885RAB9A 1972/4885KCNMA1 4571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.