Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
| ▸ | RXRG | P48443 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29692496 | 0.99 | HRH4 (0.44) | HRH4HRH3HDAC3HDAC4HDAC1 | |
| SCHEMBL21648324 | 0.89 | HRH4 (0.44) | HRH4HRH3HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL29692460 | 0.88 | HRH4 (0.43) | HRH4HRH3HDAC3HDAC4HDAC1 | |
| SCHEMBL21648487 | 0.87 | HRH4 (0.44) | HRH4HRH3HDAC3HDAC4HDAC1 | |
| SCHEMBL21648323 | 0.87 | BCHE (0.40) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL29692502 | 0.86 | HRH4 (0.43) | HRH4HRH3HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL29692596 | 0.86 | BCHE (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL21648322 | 0.84 | HRH4 (0.50) | HRH4HRH3HDAC1CHRM2CXCR4 | |
| SCHEMBL21632590 | 0.84 | RXRA (0.35) | RXRARXRBRXRG | |
| Hydrochloric Acid SCHEMBL29692770 | 0.83 | HRH4 (0.49) | HRH4HRH3HDAC1CHRM2CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3606344-B1 | COMPOSITIONS AND METHODS COMPRISING A TRIARYL POLYAMINE | CURZA GLOBAL LLC (US) | 2022-08-17 | — | — | EP | disclosed |
| US-11352315-B2 | Compositions and methods comprising a triaryl polyamine | CURZA GLOBAL, LLC (US) | 2022-06-07 | — | — | US | disclosed |
| US-20200031757-A1 | COMPOSITIONS AND METHODS COMPRISING A TRIARYL POLYAMINE | CURZA GLOBAL, LLC (US) | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352315-B2 | Compositions and methods comprising a triaryl polyamine | SRM, PARG, PARN | HRH4 2152/4885HRH3 618/4885HDAC3 426/4885 |
| US-20200031757-A1 | COMPOSITIONS AND METHODS COMPRISING A TRIARYL POLYAMINE | SRM, PARG, PARN | HRH4 2152/4885HRH3 618/4885HDAC3 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.