Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22861802 | 0.88 | SLC22A12 (0.39) | SLC22A12ADORA3ADORA1HDAC8ADORA2A | |
| SCHEMBL21649237 | 0.83 | SLC22A12 (0.48) | SLC22A12PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27428306 | 0.78 | ALDH1A1 (0.41) | SLC22A12ADORA3ADORA1HDAC8PSEN1 | |
| SCHEMBL18999667 | 0.78 | ADORA2A (0.37) | SLC22A12ADORA3ADORA1HDAC8ADORA2A | |
| SCHEMBL13826298 | 0.78 | ADORA2A (0.55) | SLC22A12PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL26741066 | 0.78 | GRM4 (0.43) | SLC22A12PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1696383 | 0.77 | SCN9A (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17229784 | 0.77 | ATM (0.38) | ADORA2AADORA2BMAPK8ESR1SSTR4 | |
| SCHEMBL26289032 | 0.77 | PDGFRA (0.39) | SLC22A12ADORA3ADORA1HDAC8ADORA2A | |
| SCHEMBL21649255 | 0.74 | ADORA2A (0.34) | SLC22A12ADORA3ADORA1HDAC8ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230039309-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-02-09 | — | — | US | disclosed |
| US-11208415-B2 | Substituted indole Mcl-1 inhibitors | VANDERBILT UNIVERSITY (US) | 2021-12-28 | — | — | US | disclosed |
| US-11160280-B2 | Pesticial compounds | BASF SE (DE) | 2021-11-02 | — | — | US | disclosed |
| US-20210070713-A1 | PESTICIDAL COMPOUNDS | BASF SE (DE) | 2021-03-11 | — | — | US | disclosed |
| US-20200140447-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2020-05-07 | — | — | US | disclosed |
| US-20200029566-A1 | Pesticial Compounds | BASF SE (DE) | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200140447-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL3 | SLC22A12 2537/4885ADORA3 3826/4885ADORA1 3306/4885 |
| US-11160280-B2 | Pesticial compounds | PNMT, DDT, NIT2 | SLC22A12 1443/4885ADORA3 1873/4885ADORA1 1600/4885 |
| US-20230039309-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL3 | SLC22A12 2537/4885ADORA3 3826/4885ADORA1 3306/4885 |
| US-20210070713-A1 | PESTICIDAL COMPOUNDS | CAT, NIT2, PNMT | SLC22A12 1787/4885ADORA3 1474/4885ADORA1 1437/4885 |
| US-11208415-B2 | Substituted indole Mcl-1 inhibitors | MCL1, BCL2L1, BCL3 | SLC22A12 2537/4885ADORA3 3826/4885ADORA1 3306/4885 |
| US-20200029566-A1 | Pesticial Compounds | PNMT, DDT, NIT2 | SLC22A12 1443/4885ADORA3 1873/4885ADORA1 1600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.