Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 9/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22473944 | 0.89 | KDM4E (0.41) | MAP3K5HSD17B10GAAKDM4E | |
| SCHEMBL28657005 | 0.81 | ALDH1A1 (0.41) | TP53MAPTLMNAMAP3K5HPGD | |
| SCHEMBL28643394 | 0.73 | ALDH1A1 (0.41) | MAPTMAP3K5HPGDPOLBALDH1A1 | |
| SCHEMBL19258658 | 0.73 | MAP3K5 (0.64) | MAP3K5MAP3K6 | |
| SCHEMBL21155114 | 0.72 | PKM (0.38) | MAP3K5HPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL21649344 | 0.70 | MAP3K5 (0.49) | MAP3K5 | |
| SCHEMBL22474011 | 0.70 | MAP3K5 (0.51) | MAP3K5MAP3K6 | |
| SCHEMBL230868 | 0.69 | MAPT (0.36) | MAPTLMNAMAP3K5HPGDPOLB | |
| SCHEMBL28649145 | 0.69 | TP53 (0.48) | TP53MAPTLMNAHPGDCYP1A2 | |
| SCHEMBL21649295 | 0.68 | MAP3K5 (0.53) | MAP3K5MAP3K6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3572401-B1 | ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | FUJIAN COSUNTER PHARMACEUTICAL CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| US-11040968-B2 | Pyridine derivative as ASK1 inhibitor and preparation method and use thereof | FUJIAN AKEYLINK BIOTECHNOLOGY CO., LTD. (CN) | 2021-06-22 | — | — | US | disclosed |
| EP-3572412-B1 | PYRIDINE DERIVATIVE AS ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | FUJIAN COSUNTER PHARMACEUTICAL CO LTD (CN) | 2021-03-03 | — | — | EP | disclosed |
| US-10787435-B2 | ASK1 inhibitor and preparation method and use thereof | Fuijan Cosunter Pharmaceutical Co. Ltd. (CN) | 2020-09-29 | — | — | US | disclosed |
| US-20200031823-A1 | PYRIDINE DERIVATIVE AS ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | FUJUAN COSUNTER PHARMACEUTICAL CO., LTD. (CN) | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11040968-B2 | Pyridine derivative as ASK1 inhibitor and preparation method and use thereof | MARK1, MAP3K1, MAP3K11 | TP53 1152/4885MAPT 35/4885LMNA 2700/4885 |
| US-10787435-B2 | ASK1 inhibitor and preparation method and use thereof | MARK1, MAP3K1, MAP3K20 | TP53 1080/4885MAPT 25/4885LMNA 2221/4885 |
| US-20200031823-A1 | PYRIDINE DERIVATIVE AS ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | MARK1, MAP3K1, MAP3K11 | TP53 1152/4885MAPT 35/4885LMNA 2700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.