Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19456159 | 0.86 | BRD4 (0.39) | BRD4 | |
| SCHEMBL21649948 | 0.84 | FUCA1 (0.37) | BRD4MAPK14 | |
| SCHEMBL19456188 | 0.83 | PARP1 (0.32) | — | |
| SCHEMBL19456199 | 0.82 | BRD4 (0.56) | BRD4 | |
| SCHEMBL19456404 | 0.81 | PARP1 (0.34) | RAB9APOLBHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL19456162 | 0.78 | BRD4 (0.52) | BRD4 | |
| SCHEMBL19456132 | 0.74 | RXFP1 (0.33) | BRD4POLBHPGDALDH1A1KDM4E | |
| SCHEMBL19456190 | 0.73 | BRD4 (0.49) | BRD4 | |
| SCHEMBL19456231 | 0.73 | BRD4 (0.58) | BRD4 | |
| SCHEMBL19456172 | 0.73 | BRD4 (0.60) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440075-B1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-01-29 | — | — | EP | disclosed |