Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19456159 | 0.86 | BRD4 (0.39) | PARP1 | |
| SCHEMBL19456109 | 0.85 | MAPT (0.34) | — | |
| SCHEMBL21649948 | 0.84 | FUCA1 (0.37) | PARP1 | |
| SCHEMBL21649777 | 0.83 | TAS1R3 (0.40) | — | |
| SCHEMBL19456404 | 0.81 | PARP1 (0.34) | PARP1 | |
| SCHEMBL19456132 | 0.74 | RXFP1 (0.33) | PARP1 | |
| SCHEMBL19456190 | 0.73 | BRD4 (0.49) | — | |
| SCHEMBL19456276 | 0.72 | BRD4 (0.38) | PARP1 | |
| SCHEMBL19456376 | 0.72 | BRD4 (0.45) | — | |
| SCHEMBL21649942 | 0.71 | BRD4 (0.52) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440075-B1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-01-29 | — | — | EP | disclosed |
| WO-2017174620-A1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-10-12 | — | — | WO | disclosed |