Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14838175 | 0.85 | KDM4E (0.43) | MAPTKDM4ELMNAHTTTP53 | |
| SCHEMBL17057334 | 0.81 | MAPT (0.43) | MAPTKDM4ELMNAHTTCYP3A4 | |
| SCHEMBL26664996 | 0.78 | MAPT (0.41) | MAPTKDM4ELMNAHTTTP53 | |
| SCHEMBL19017627 | 0.78 | KDM4E (0.41) | MAPTKDM4ELMNAHTTTP53 | |
| SCHEMBL21298009 | 0.76 | — | — | |
| SCHEMBL20726017 | 0.75 | DHODH (0.49) | MAPTKDM4ELMNAHTTTP53 | |
| SCHEMBL15966239 | 0.74 | ALDH1A1 (0.41) | MAPTKDM4ELMNAHTTALDH1A1 | |
| SCHEMBL23969176 | 0.72 | MAPT (0.53) | MAPTKDM4ELMNAHTTTP53 | |
| SCHEMBL20663401 | 0.72 | MAPT (0.53) | MAPTKDM4ELMNAHTTTP53 | |
| SCHEMBL18874808 | 0.72 | MAPT (0.42) | MAPTKDM4ELMNAHTTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023802-A1 | PARG INHIBITORS AND METHOD OF USE THEREOF | CITY OF HOPE (US) | 2020-01-30 | — | — | WO | disclosed |