Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20663401 | 1.00 | MAPT (0.53) | MAPTNPC1RAB9APKMMAPK1 | |
| SCHEMBL14533781 | 0.79 | MAPT (0.49) | MAPTNPC1RAB9APKMMAPK1 | |
| SCHEMBL20726017 | 0.78 | DHODH (0.49) | MAPTNPC1RAB9APKMMAPK1 | |
| SCHEMBL14538303 | 0.78 | NPC1 (0.57) | MAPTNPC1RAB9APKMMAPK1 | |
| SCHEMBL18874808 | 0.75 | MAPT (0.42) | MAPTNPC1RAB9APKMMAPK1 | |
| SCHEMBL16130312 | 0.75 | MAPT (0.42) | MAPTNPC1RAB9APKMMAPK1 | |
| SCHEMBL17082217 | 0.75 | ALDH1A1 (0.43) | MAPTNPC1RAB9AMAPK1L3MBTL1 | |
| SCHEMBL21131297 | 0.74 | CYP3A4 (0.62) | MAPTNPC1RAB9APKML3MBTL1 | |
| SCHEMBL8292092 | 0.74 | CYP3A4 (0.62) | MAPTNPC1RAB9APKML3MBTL1 | |
| SCHEMBL20663341 | 0.74 | RAB9A (0.57) | MAPTNPC1RAB9APKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3904357-A1 | SPIRO COMPOUND AND MEDICAL USES THEREOF | The National Institutes of Pharmaceutical R&D Co., Ltd (CN) | 2021-11-03 | — | — | EP | disclosed |