Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21652917 | 0.89 | MEN1 (0.41) | MAPTALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL21653107 | 0.86 | ALDH1A1 (0.40) | PTGDR2MAPTALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL21652898 | 0.81 | MAPT (0.42) | MAPTALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL21652890 | 0.79 | KDM4E (0.41) | MAPTALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL21653265 | 0.79 | MEN1 (0.44) | MAPTALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL21653390 | 0.74 | SMN1; SMN2 (0.44) | MAPTALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL21653233 | 0.74 | MAPT (0.39) | PTGDR2MAPTALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL21652916 | 0.74 | MAPT (0.47) | MAPTALDH1A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL21653268 | 0.72 | MAPT (0.41) | PTGDR2MAPTALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL21653263 | 0.71 | ALDH1A1 (0.42) | MAPTALDH1A1CYP2C9CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |