Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ACR | P10323 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653119 | 0.87 | ALDH1A1 (0.43) | MAPTCYP2C9CYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL21652867 | 0.85 | ALDH1A1 (0.39) | MAPTSNCAPOLBCYP2C9CYP2C19 | |
| SCHEMBL21653233 | 0.77 | MAPT (0.39) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL21652971 | 0.75 | MEN1 (0.41) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL21652881 | 0.74 | MEN1 (0.43) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL21653107 | 0.74 | ALDH1A1 (0.40) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL21653361 | 0.73 | MEN1 (0.40) | MAPTSNCAKMT2AMEN1NPC1 | |
| SCHEMBL21653349 | 0.72 | MEN1 (0.35) | MAPTROCK1KMT2AMEN1NPC1 | |
| SCHEMBL21653126 | 0.72 | PTGDR2 (0.39) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL21653053 | 0.68 | DAO (0.45) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |