Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | TOP1 | P11387 | 3/20 | 0.45 |
| ▸ | MT-CO2 | P00403 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653087 | 0.73 | RAB9A (0.56) | NPC1RAB9A | |
| SCHEMBL16430801 | 0.73 | SMN1; SMN2 (0.68) | PTGS2KCNK3KCNK9ACKR3 | |
| SCHEMBL18171803 | 0.72 | DAO (0.38) | NPC1RAB9A | |
| SCHEMBL21653175 | 0.71 | NPC1 (0.47) | TP53KCNK3KCNK9NPC1RAB9A | |
| SCHEMBL16430921 | 0.69 | SMN1; SMN2 (0.62) | DHODHTP53NPC1RAB9A | |
| SCHEMBL10126900 | 0.69 | TAS1R3 (0.54) | PTGS2MT-CO2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL18118631 | 0.68 | DHODH (0.67) | DHODHKCNK3KCNK9NPC1RAB9A | |
| SCHEMBL19799127 | 0.68 | DHODH (0.68) | DHODHTP53KCNK3KCNK9NPC1 | |
| SCHEMBL3455263 | 0.68 | CYP1A2 (0.70) | TP53KCNK3KCNK9NPC1RAB9A | |
| SCHEMBL16054667 | 0.68 | TAS1R3 (0.52) | PTGS2MT-CO2TAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |