Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 10/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | USP7 | Q93009 | 3/20 | 0.34 |
| ▸ | USP47 | Q96K76 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653160 | 0.92 | MEN1 (0.35) | ARMEN1KMT2ARXFP1XDH | |
| SCHEMBL21653232 | 0.84 | MAPT (0.34) | ARMEN1KMT2AMAPTMAPK1 | |
| SCHEMBL21653254 | 0.82 | LRRK2 (0.37) | ARMEN1KMT2ARXFP1XDH | |
| SCHEMBL21653072 | 0.82 | KMT2A (0.38) | MEN1KMT2ARXFP1ALDH1A1HPGD | |
| SCHEMBL21653279 | 0.79 | USP7 (0.38) | ARUSP7USP47RXFP1MAPT | |
| SCHEMBL21653143 | 0.79 | MAPT (0.36) | ARMEN1KMT2AUSP7USP47 | |
| SCHEMBL21633869 | 0.78 | TP53 (0.35) | MEN1KMT2ARXFP1ALDH1A1HPGD | |
| SCHEMBL21652928 | 0.78 | MAPT (0.36) | ARMEN1KMT2AUSP7USP47 | |
| SCHEMBL21653075 | 0.77 | KMT2A (0.36) | MEN1KMT2AUSP7RXFP1ALDH1A1 | |
| SCHEMBL21653264 | 0.74 | MAPT (0.36) | ARMEN1KMT2ARXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |