Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 3/20 | 0.38 |
| ▸ | USP47 | Q96K76 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.33 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.33 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653089 | 0.89 | PDE10A (0.35) | USP7USP47MAPTTP53L3MBTL1 | |
| SCHEMBL21653276 | 0.87 | L3MBTL1 (0.36) | USP7USP47RORCMAPTTP53 | |
| SCHEMBL21653120 | 0.86 | GSK3B (0.39) | MAPTTP53RXFP1PDE10ASMN1; SMN2 | |
| SCHEMBL21653078 | 0.85 | USP7 (0.39) | USP7USP47RORCPFKFB2PFKFB1 | |
| SCHEMBL21653261 | 0.82 | LRRK2 (0.39) | USP7USP47RORCMAPTTP53 | |
| SCHEMBL21653277 | 0.79 | AR (0.35) | USP7USP47MAPTRXFP1AR | |
| SCHEMBL21653084 | 0.77 | MAPT (0.39) | MAPTTP53L3MBTL1PDE10ASMN1; SMN2 | |
| SCHEMBL21653251 | 0.77 | GSK3B (0.38) | MAPTTP53L3MBTL1RXFP1PDE10A | |
| SCHEMBL21653081 | 0.76 | SMN1; SMN2 (0.38) | MAPTTP53RXFP1PDE10ASMN1; SMN2 | |
| SCHEMBL21653156 | 0.76 | PDE10A (0.38) | MAPTTP53RXFP1PDE10ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |