⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22833216 | 0.76 | — | — | |
| SCHEMBL14986261 | 0.76 | — | — | |
| SCHEMBL13568091 | 0.74 | TSHR (0.34) | — | |
| SCHEMBL2614492 | 0.74 | — | — | |
| SCHEMBL12763598 | 0.74 | SELE (0.37) | — | |
| SCHEMBL11520288 | 0.73 | — | — | |
| SCHEMBL4595703 | 0.73 | — | — | |
| SCHEMBL2417707 | 0.73 | — | — | |
| SCHEMBL12724787 | 0.72 | MAPK14 (0.31) | — | |
| SCHEMBL27398504 | 0.70 | MEN1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208952-A1 | THIOPHENE GLP-1 RECEPTOR AGONIST AND USE THEREOF | HANGZHOU ZHONGMEIHUADONG PHARMACEUTICAL CO., LTD. (CN) | 2024-06-27 | — | — | US | disclosed |
| US-20240208952-A1 | THIOPHENE GLP-1 RECEPTOR AGONIST AND USE THEREOF | HANGZHOU ZHONGMEIHUADONG PHARMACEUTICAL CO., LTD. (CN) | 2024-06-27 | — | — | US | disclosed |
| US-20220363673-A1 | 5-(Thiophen-2-YL)-1 H-Tetrazole Derivative as BCKDK Inhibitors Useful for Treating Various Diseases | PFIZER INC. (US) | 2022-11-17 | — | — | US | disclosed |
| EP-3990452-A1 | 5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES | Pfizer Inc. (US) | 2022-05-04 | — | — | EP | disclosed |
| WO-2020261144-A1 | 5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES | PFIZER INC. (US) | 2020-12-30 | — | — | WO | disclosed |
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |