⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14986261 | 0.76 | — | — | |
| SCHEMBL95334 | 0.76 | — | — | |
| SCHEMBL13568091 | 0.74 | TSHR (0.34) | — | |
| SCHEMBL2614492 | 0.74 | — | — | |
| SCHEMBL21653333 | 0.73 | — | — | |
| SCHEMBL11520288 | 0.73 | — | — | |
| SCHEMBL2417707 | 0.73 | — | — | |
| SCHEMBL22833057 | 0.72 | MME (0.44) | — | |
| SCHEMBL18122960 | 0.72 | PGR (0.39) | — | |
| SCHEMBL31261454 | 0.69 | MME (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250326773-A1 | MRGPRX2 ANTAGONISTS, PHARMACEUTICAL COMPOSITION INCLUDING MRGPRX2 ANTAGONIST, AND METHOD OF TREATING MRGPRX2-MEDIATED DISEASE OR DISORDER | KYORIN SEIYAKU KK (JP) | 2025-10-23 | — | — | US | disclosed |
| US-20250326772-A1 | MRGPRX2 ANTAGONISTS, PHARMACEUTICAL COMPOSITION INCLUDING MRGPRX2 ANTAGONIST, AND METHOD OF TREATING MRGPRX2-MEDIATED DISEASE OR DISORDER | KYORIN SEIYAKU KK (JP) | 2025-10-23 | — | — | US | disclosed |
| EP-1539731-B9 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| US-7329686-B2 | Substituted thiophene compounds | ASTRAZENECA AB (SE) | 2008-02-12 | — | — | US | disclosed |
| EP-1539731-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-02 | — | — | EP | disclosed |
| US-20060019999-A1 | Specific inhibitors of one or more isoforms of nitric oxide synthase; 3-[[2-amino-1-phenylethyl]thio]-5-methyl-2-thiophenecarbonitrile; antiinflammatory agent; pain | ASTRAZENECA AB (SE) | 2006-01-26 | — | — | US | disclosed |
| US-20050203172-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2005-09-15 | — | — | US | disclosed |
| EP-1539731-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004009580-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-01-29 | — | — | WO | disclosed |