Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 20/20 | 0.75 |
| ▸ | PLA2G1B | P04054 | 5/20 | 0.60 |
| ▸ | PLA2G10 | O15496 | 4/20 | 0.58 |
| ▸ | PLA2G5 | P39877 | 4/20 | 0.58 |
| ▸ | PLA2G2F | Q9BZM2 | 3/20 | 0.58 |
| ▸ | PLA2G2E | Q9NZK7 | 3/20 | 0.58 |
| ▸ | PLA2G2D | Q9UNK4 | 3/20 | 0.58 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.58 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.58 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.58 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.58 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7181794 | 0.89 | PLA2G2A (0.74) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL5319862 | 0.88 | PLA2G2A (0.77) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL7740560 | 0.86 | PLA2G2A (0.56) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL818498 | 0.86 | PLA2G2A (1.00) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL820017 | 0.83 | PLA2G2A (0.84) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL13888559 | 0.83 | PLA2G2A (0.72) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL8504097 | 0.81 | PLA2G2A (0.69) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL13888745 | 0.81 | PLA2G2A (0.75) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL7745409 | 0.81 | PLA2G2A (0.50) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL2164905 | 0.80 | PLA2G2A (0.74) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2341045-A1 | [[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-11H-indol-4-yl]oxy]acetic acid (acyloxy)alkyl or ((alkoxycarbonyl)oxy)alkyl ester as SPLA2 inhibitor | Eli Lilly and Company (US) | 2011-07-06 | — | — | EP | disclosed |