Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 20/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 4/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 4/20 | 0.42 |
| ▸ | PLA2G5 | P39877 | 4/20 | 0.42 |
| ▸ | PLA2G2F | Q9BZM2 | 3/20 | 0.39 |
| ▸ | PLA2G2E | Q9NZK7 | 3/20 | 0.39 |
| ▸ | PLA2G2D | Q9UNK4 | 3/20 | 0.39 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.39 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.39 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.39 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.39 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740560 | 0.94 | PLA2G2A (0.56) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL5697130 | 0.86 | PLA2G2A (0.68) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL7745131 | 0.85 | PLA2G2A (0.41) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL5697018 | 0.83 | PLA2G2A (0.55) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL7745773 | 0.83 | PLA2G2A (0.53) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL5697176 | 0.81 | PLA2G2A (0.75) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL2165769 | 0.81 | PLA2G2A (0.75) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL5697108 | 0.77 | PLA2G2A (0.61) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL7747977 | 0.76 | PLA2G2A (0.52) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2F | |
| SCHEMBL7181794 | 0.73 | PLA2G2A (0.74) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100492-A4 | INDOLE sPLA 2? INHIBITORS | LILLY CO ELI (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1100492-A1 | INDOLE sPLA 2? INHIBITORS | Eli Lilly & Company (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000007590-A1 | INDOLE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-02-17 | — | — | WO | disclosed |