Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.61 |
| ▸ | DRD3 | P35462 | 10/20 | 0.53 |
| ▸ | DRD4 | P21917 | 10/20 | 0.51 |
| ▸ | HTR1A | P08908 | 7/20 | 0.51 |
| ▸ | DRD1 | P21728 | 7/20 | 0.51 |
| ▸ | DRD5 | P21918 | 7/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | EBP | Q15125 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21658547 | 0.89 | CARM1 (0.61) | DRD2CARM1PRMT6SIGMAR1PRCP | |
| SCHEMBL3454031 | 0.76 | DRD2 (1.00) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL29914667 | 0.76 | DRD2 (1.00) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL21633140 | 0.76 | DRD2 (0.47) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL4827157 | 0.74 | DRD2 (0.87) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL11454403 | 0.74 | CARM1 (0.49) | DRD2DRD3CARM1PRMT6SIGMAR1 | |
| SCHEMBL7319550 | 0.73 | SIGMAR1 (0.74) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL4819670 | 0.73 | DRD2 (0.78) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL16835036 | 0.73 | DRD2 (0.68) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL19235999 | 0.73 | DRD2 (0.72) | DRD2DRD3DRD4HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020021021-A1 | ORTHO SUBSTITUTED PHENOXYPROPYLAMINO AND BENZYLOXYPROPYLAMINO DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-01-30 | — | — | WO | disclosed |