Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 7/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.75 |
| ▸ | HTR1A | P08908 | 6/20 | 0.75 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.75 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.75 |
| ▸ | DRD3 | P35462 | 6/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.75 |
| ▸ | DRD1 | P21728 | 5/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.75 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.75 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.75 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.75 |
| ▸ | BCHE | P06276 | 3/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethopropazine SCHEMBL34046 | 0.86 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Ethopropazine SCHEMBL29426328 | 0.86 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Ethopropazine SCHEMBL34045 | 0.86 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| (S)-Promethazine SCHEMBL2900853 | 0.85 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL26777 | 0.85 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL29372077 | 0.85 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL4700 | 0.85 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Ethopropazine SCHEMBL30516992 | 0.84 | ALDH1A1 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Ethopropazine SCHEMBL123703 | 0.84 | ALDH1A1 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Ethopropazine SCHEMBL123702 | 0.84 | ALDH1A1 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10869933-B2 | Oligomer-phenothiazine conjugates | NEKTAR THERAPEUTICS (US) | 2020-12-22 | — | — | US | disclosed |
| US-20200038517-A1 | OLIGOMER-PHENOTHIAZINE CONJUGATES | NEKTAR THERAPEUTICS (US) | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10869933-B2 | Oligomer-phenothiazine conjugates | HTT, MAPT, SLCO1B3 | CYP2D6 283/4885CHRM2 973/4885HTR1A 518/4885 |
| US-20200038517-A1 | OLIGOMER-PHENOTHIAZINE CONJUGATES | HTT, MAPT, SLCO1B3 | CYP2D6 283/4885CHRM2 973/4885HTR1A 518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.