Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19010252 | 0.81 | KDM4E (0.40) | KDM4EKDM1AMEN1KMT2AALDH1A1 | |
| SCHEMBL27410749 | 0.81 | KDM4E (0.40) | KDM4EKDM1AMEN1KMT2AALDH1A1 | |
| SCHEMBL27410751 | 0.81 | KDM4E (0.40) | KDM4EKDM1AMEN1KMT2AALDH1A1 | |
| SCHEMBL15330120 | 0.77 | SIGMAR1 (0.38) | KDM4EKDM1AMEN1KMT2AALDH1A1 | |
| SCHEMBL11293431 | 0.77 | ATM (0.50) | KDM4EMEN1KMT2AALDH1A1SIGMAR1 | |
| SCHEMBL23866534 | 0.73 | KDM4E (0.53) | KDM4EMEN1KMT2AALDH1A1ATM | |
| SCHEMBL19045054 | 0.73 | KDM4E (0.53) | KDM4EMEN1KMT2AALDH1A1ATM | |
| SCHEMBL25493325 | 0.72 | HRH3 (0.37) | HRH3KCNQ3KCNQ2 | |
| SCHEMBL178416 | 0.72 | HRH3 (0.44) | HRH3 | |
| SCHEMBL17642614 | 0.72 | POLB (0.58) | KDM4EKMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020025517-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-02-06 | — | — | WO | disclosed |