Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 6/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21666534 | 0.95 | PDK2 (0.38) | PDK2PTGS2PTGS1ELANEAHR | |
| SCHEMBL21666445 | 0.94 | PDK2 (0.40) | PDK2PTGS2PTGS1ELANEAHR | |
| SCHEMBL21666306 | 0.86 | PDK2 (0.38) | PDK2ELANEMAPK1KDM4ENPC1 | |
| SCHEMBL30484149 | 0.84 | PDK2 (0.44) | PDK2PTGS2PTGS1SLC6A4SLC6A3 | |
| SCHEMBL19283454 | 0.84 | PDK2 (0.44) | PDK2PTGS2PTGS1SLC6A4SLC6A3 | |
| SCHEMBL23931062 | 0.82 | PDK2 (0.46) | PDK2PTGS2PTGS1SLC6A4SLC6A3 | |
| SCHEMBL30484155 | 0.82 | PDK2 (0.46) | PDK2PTGS2PTGS1SLC6A4SLC6A3 | |
| SCHEMBL24027620 | 0.82 | ELANE (0.35) | PDK2PTGS2PTGS1ELANEAHR | |
| SCHEMBL23028724 | 0.82 | SMN1; SMN2 (0.42) | PDK2AHRSLC6A4SLC6A3MAOB | |
| SCHEMBL21666300 | 0.81 | PDK2 (0.43) | PDK2AHRMAOBMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255151-A2 | SPIRO[FLUORENE-9,9'-(THIO)XANTHENE] COMPOUNDS | Merck Patent GmbH (DE) | 2023-10-04 | — | — | EP | disclosed |
| EP-4113643-B1 | SPIRO[FLUORENE-9,9'-(THIO)XANTHENE] COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-08-09 | — | — | EP | disclosed |
| EP-3523834-B1 | ELECTRONIC DEVICE | MERCK PATENT GMBH (DE) | 2023-01-25 | — | — | EP | disclosed |
| EP-4113643-A1 | ELECTRONIC DEVICE | Merck Patent GmbH (DE) | 2023-01-04 | — | — | EP | disclosed |
| US-20200044160-A1 | ELECTRONIC DEVICE | MERCK PATENT GMBH (DE) | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200044160-A1 | ELECTRONIC DEVICE | XDH, AOX1, OCIAD1 | PDK2 955/4885PTGS2 2166/4885PTGS1 2399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.