Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 3/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667364 | 0.88 | SMN1; SMN2 (0.46) | GPR84ADORA1PIK3CAPIK3CBMEN1 | |
| SCHEMBL21667340 | 0.87 | ADORA2A (0.45) | GPR84ADORA1PRKCQMEN1ALDH1A1 | |
| SCHEMBL21667342 | 0.84 | GRIN1 (0.52) | ADORA1CARM1PRMT6P2RX7 | |
| SCHEMBL21667387 | 0.83 | PGR (0.47) | PDE9AGPR84POLBADORA1PIK3CA | |
| SCHEMBL21667382 | 0.81 | ADORA1 (0.49) | PDE9AGPR84POLBADORA1PIK3CA | |
| SCHEMBL16340892 | 0.77 | SMN1; SMN2 (0.48) | PDE9AMEN1ALDH1A1CYP3A4KMT2A | |
| SCHEMBL16340893 | 0.77 | SMN1; SMN2 (0.48) | PDE9AMEN1ALDH1A1CYP3A4KMT2A | |
| SCHEMBL21667306 | 0.76 | CYP3A4 (0.50) | PDE9AGPR84POLBPIK3CAPIK3CB | |
| SCHEMBL17476762 | 0.69 | SMN1; SMN2 (0.62) | PDE9AADORA1MEN1ALDH1A1CYP3A4 | |
| SCHEMBL16356145 | 0.69 | SMN1; SMN2 (0.62) | PDE9AADORA1MEN1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |