Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 6/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667340 | 0.85 | ADORA2A (0.45) | GRIN1GRIN2BADORA3ADORA2BCARM1 | |
| SCHEMBL21667282 | 0.84 | PDE9A (0.43) | CARM1PRMT6ADORA1P2RX7 | |
| SCHEMBL21667281 | 0.84 | EGFR (0.53) | ADORA2BEGFRCHEK1DAPK3ROCK2 | |
| SCHEMBL21667364 | 0.84 | SMN1; SMN2 (0.46) | GRIN1GRIN2BADORA3ADORA2BADORA2A | |
| SCHEMBL21667344 | 0.82 | EGFR (0.54) | ADORA3ADORA2BEGFRCHEK1DAPK3 | |
| SCHEMBL16341265 | 0.79 | GRIN1 (0.48) | GRIN1GRIN2BADORA3ADORA2BCRHR1 | |
| SCHEMBL16341264 | 0.79 | GRIN1 (0.48) | GRIN1GRIN2BADORA3ADORA2BCRHR1 | |
| SCHEMBL21667214 | 0.70 | SMN1; SMN2 (0.47) | — | |
| SCHEMBL22186997 | 0.69 | CNR1 (0.50) | EGFRGAA | |
| SCHEMBL29888077 | 0.68 | GRIN1 (1.00) | GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |