Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667192 | 0.79 | MEN1 (0.53) | KMT2AMEN1HSD17B10TP53SMN1; SMN2 | |
| SCHEMBL16356146 | 0.77 | KMT2A (0.38) | KMT2AMEN1GLAHSD17B10TP53 | |
| SCHEMBL17476757 | 0.77 | KMT2A (0.38) | KMT2AMEN1GLAHSD17B10TP53 | |
| SCHEMBL21667376 | 0.74 | KMT2A (0.53) | KMT2AMEN1GLAHSD17B10GPR84 | |
| SCHEMBL21667390 | 0.69 | POLB (0.39) | KMT2AMEN1GLAHSD17B10SMN1; SMN2 | |
| SCHEMBL22521704 | 0.68 | SMN1; SMN2 (0.76) | KMT2AMEN1GLAHSD17B10GPR84 | |
| SCHEMBL16321200 | 0.67 | SMN1; SMN2 (0.63) | KMT2AMEN1HSD17B10SMN1; SMN2MAPT | |
| SCHEMBL16321199 | 0.67 | SMN1; SMN2 (0.63) | KMT2AMEN1HSD17B10SMN1; SMN2MAPT | |
| SCHEMBL22521701 | 0.66 | TP53 (0.72) | KMT2AMEN1GLAHSD17B10GPR84 | |
| SCHEMBL21667343 | 0.65 | MEN1 (0.61) | KMT2AMEN1HSD17B10GPR84TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |