Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667192 | 0.75 | MEN1 (0.53) | POLBMEN1KMT2AMAPTLMNA | |
| SCHEMBL21667221 | 0.73 | CYP3A4 (0.34) | — | |
| SCHEMBL21667379 | 0.69 | KMT2A (0.57) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL16341721 | 0.62 | HTT (0.31) | MEN1KMT2AMAPTSMN1; SMN2TSHR | |
| SCHEMBL21667343 | 0.62 | MEN1 (0.61) | POLBMEN1KMT2AMAPTLMNA | |
| SCHEMBL16321199 | 0.61 | SMN1; SMN2 (0.63) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL16322326 | 0.61 | FFAR4 (0.32) | ALDH1A1SMN1; SMN2TSHRHSD17B10GLA | |
| SCHEMBL21667355 | 0.58 | MEN1 (0.47) | POLBMEN1KMT2AMAPTLMNA | |
| SCHEMBL21667345 | 0.57 | ALDH1A1 (0.55) | POLBMEN1KMT2AMAPTLMNA | |
| SCHEMBL21667268 | 0.57 | MEN1 (0.60) | POLBMEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |