Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22383610 | 0.91 | TP53 (0.52) | KMT2AMEN1GLAHSD17B10SMN1; SMN2 | |
| SCHEMBL16321957 | 0.82 | CYP3A4 (0.41) | KMT2AMEN1GLAHSD17B10SMN1; SMN2 | |
| SCHEMBL16321961 | 0.82 | CYP3A4 (0.41) | KMT2AMEN1GLAHSD17B10SMN1; SMN2 | |
| SCHEMBL21667277 | 0.78 | SMN1; SMN2 (0.49) | KMT2AMEN1GLASMN1; SMN2TP53 | |
| SCHEMBL21667332 | 0.76 | CYP3A4 (0.49) | KMT2AMEN1GLAHSD17B10SMN1; SMN2 | |
| SCHEMBL21667365 | 0.76 | SMN1; SMN2 (0.70) | KMT2AMEN1GLAHSD17B10SMN1; SMN2 | |
| SCHEMBL21667379 | 0.74 | KMT2A (0.57) | KMT2AMEN1GLAHSD17B10SMN1; SMN2 | |
| SCHEMBL21667352 | 0.73 | KMT2A (0.41) | KMT2AMEN1GLAHSD17B10SMN1; SMN2 | |
| SCHEMBL22383609 | 0.73 | CYP3A4 (0.41) | KMT2AMEN1HSD17B10SMN1; SMN2TP53 | |
| SCHEMBL22521704 | 0.69 | SMN1; SMN2 (0.76) | KMT2AMEN1GLAHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |