Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29392568 | 1.00 | CYP11B2 (0.43) | CYP11B2KDM4EALDH1A1L3MBTL1DYRK1A | |
| SCHEMBL21672276 | 0.81 | PRPS1 (0.33) | DYRK1APRPS1JAK2JAK3CHEK1 | |
| SCHEMBL21644166 | 0.79 | DYRK1A (0.65) | CYP11B2KDM4EALDH1A1L3MBTL1DYRK1A | |
| SCHEMBL3854984 | 0.75 | CYP11B2 (0.43) | CYP11B2KDM4EALDH1A1L3MBTL1DYRK1A | |
| SCHEMBL3851521 | 0.72 | CYP11B2 (0.43) | CYP11B2KDM4EALDH1A1L3MBTL1DYRK1A | |
| SCHEMBL10552778 | 0.71 | POLB (0.55) | CYP11B2KDM4EALDH1A1L3MBTL1FGFR1 | |
| SCHEMBL1461384 | 0.67 | CYP11B2 (0.49) | CYP11B2KDM4EALDH1A1L3MBTL1SMO | |
| SCHEMBL13137285 | 0.66 | DPP4 (0.41) | L3MBTL1DYRK1APRPS1DPP4DPP8 | |
| SCHEMBL21608349 | 0.64 | CDC7 (0.43) | CYP11B2KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL10548057 | 0.63 | CYP11B2 (0.64) | CYP11B2KDM4EALDH1A1L3MBTL1SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200039989-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200039989-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | CLK2, CLK1, CLK3 | CYP11B2 2795/4885KDM4E 2963/4885ALDH1A1 2781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.