Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31335508 | 0.86 | TSHR (0.44) | ALDH1A1TSHRALOX5MAPTSMN1; SMN2 | |
| SCHEMBL20521373 | 0.85 | ALDH1A1 (0.50) | ALDH1A1TSHRALOX5MAPTSMN1; SMN2 | |
| SCHEMBL466109 | 0.85 | ALDH1A1 (0.50) | ALDH1A1TSHRALOX5MAPTSMN1; SMN2 | |
| SCHEMBL16334854 | 0.85 | NR1H4 (0.48) | ALDH1A1TSHRMAPTSMN1; SMN2NPC1 | |
| SCHEMBL16334855 | 0.85 | NR1H4 (0.48) | ALDH1A1TSHRMAPTSMN1; SMN2NPC1 | |
| SCHEMBL23743658 | 0.80 | L3MBTL1 (0.46) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL24703878 | 0.80 | L3MBTL1 (0.46) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL715040 | 0.80 | ALDH1A1 (0.43) | ALDH1A1TSHRMAPTSMN1; SMN2MAOB | |
| SCHEMBL24425868 | 0.80 | ALDH1A1 (0.43) | ALDH1A1TSHRMAPTSMN1; SMN2MAOB | |
| SCHEMBL21017017 | 0.78 | TSHR (0.50) | ALDH1A1TSHRALOX5MAPTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11168064-B2 | Synthesis of thapsigargin, nortrilobolide, and analogs thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2021-11-09 | — | — | US | disclosed |
| US-20200031793-A1 | Synthesis of Thapsigargin, Nortrilobolide, and Analogs Thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031793-A1 | Synthesis of Thapsigargin, Nortrilobolide, and Analogs Thereof | HSPA5, ATP2A1, CYP51A1 | ALDH1A1 3277/4885TSHR 2571/4885ALOX5 79/4885 |
| US-11168064-B2 | Synthesis of thapsigargin, nortrilobolide, and analogs thereof | HSPA5, ATP2A1, CYP51A1 | ALDH1A1 3277/4885TSHR 2571/4885ALOX5 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.