SCHEMBL21676150

SCHEMBL21676150

c1ccc2c(-n3c4ccccc4c4ccc5c(c6c7ccccc7ccc6n5-c5ccc6c(c5)-c5cccc7cccc-6c57)c43)cccc2c1

nearest known ligand 0.33

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.33
TSHR P16473 3/20 0.33
MAPK1 P28482 3/20 0.33
HSD17B10 Q99714 3/20 0.33
HPGD P15428 2/20 0.33
CASP1 P29466 2/20 0.33
HIF1A Q16665 2/20 0.33
TP53 P04637 1/20 0.33
CASP7 P55210 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 3/20 0.33
ATM Q13315 2/20 0.33
ANPEP P15144 1/20 0.32
POLB P06746 1/20 0.32
BRD1 O95696 1/20 0.31
KDM4E B2RXH2 1/20 0.31
PDE6D O43924 1/20 0.30
DUSP3 P51452 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21676134 0.92 ALDH1A1 (0.34) ALDH1A1TSHRMAPK1HSD17B10HPGD
SCHEMBL21676165 0.91 L3MBTL1 (0.39) ALDH1A1TSHRMAPK1HSD17B10HPGD
SCHEMBL21676148 0.91 ANPEP (0.35) ALDH1A1TSHRMAPK1HSD17B10HPGD
SCHEMBL21676180 0.90 ALDH1A1 (0.33) ALDH1A1TSHRMAPK1HSD17B10HPGD
SCHEMBL21676158 0.89 PDE6D (0.35) ALDH1A1TSHRMAPK1HSD17B10HPGD
SCHEMBL21676149 0.88 ATM (0.33) ALDH1A1TSHRMAPK1HSD17B10HPGD
SCHEMBL17341218 0.87 ALDH1A1 (0.41) ALDH1A1TSHRMAPK1HSD17B10HPGD
SCHEMBL19213863 0.87 PDE6D (0.33) ALDH1A1TSHRMAPK1HSD17B10HPGD
SCHEMBL22211891 0.86 ALDH1A1 (0.38) ALDH1A1TSHRMAPK1HSD17B10HPGD
SCHEMBL21676174 0.86 ANPEP (0.34) ALDH1A1TSHRMAPK1HSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020026133-A1 POLYCYCLIC COMPOUND, ORGANIC ELECTROLUMINESCENCE DEVICE, AND ELECTRONIC DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2020-02-06 WO disclosed