Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 18/20 | 1.00 |
| ▸ | CCR2 | P41597 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12221307 | 0.89 | CCR9 (0.84) | CCR9LMNAHTTTP53MAPT | |
| SCHEMBL343002 | 0.89 | CCR9 (0.81) | CCR9LMNAHTTTP53MAPT | |
| SCHEMBL13693100 | 0.88 | CCR9 (0.78) | CCR9LMNAHTTTP53MAPT | |
| SCHEMBL344016 | 0.85 | CCR9 (1.00) | CCR9LMNAHTT | |
| SCHEMBL344490 | 0.84 | CCR9 (0.72) | CCR9CCR2 | |
| SCHEMBL13693107 | 0.83 | CCR9 (0.77) | CCR9LMNAHTTTP53MAPT | |
| SCHEMBL343218 | 0.83 | CCR9 (0.77) | CCR9LMNAHTTTP53MAPT | |
| SCHEMBL343875 | 0.83 | CCR9 (1.00) | CCR9 | |
| SCHEMBL343741 | 0.83 | CCR9 (0.73) | CCR9 | |
| SCHEMBL10248530 | 0.82 | CCR9 (0.77) | CCR9CCR2LMNAHTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1798223-B2 | Aryl sulfonamides | CHEMOCENTRYX INC (US) | 2014-07-30 | — | — | EP | claimed |
| EP-1798223-B1 | Aryl sulfonamides | CHEMOCENTRYX INC (US) | 2011-07-20 | — | — | EP | claimed |
| US-20150080351-A1 | ARYL SULFONAMIDES | CHEMOCENTRYX, INC. | 2015-03-19 | — | — | US | disclosed |
| US-20130267492-A1 | ARYL SULFONAMIDES | CHEMOCENTRYX, INC. (US) | 2013-10-10 | — | — | US | disclosed |
| US-8211896-B2 | Aryl sulfonamides | CHEMOCENTRYX, INC. (US) | 2012-07-03 | — | — | US | disclosed |
| US-20120014997-A1 | ARYL SULFONAMIDES | UNGASHE SOLOMON (US) | 2012-01-19 | — | — | US | disclosed |
| US-20110021523-A1 | ARYL SULFONAMIDES | CHEMOCENTRYX, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-20090270616-A1 | ARYL SULFONAMIDES | CHEMOCENTRYX, INC (US) | 2009-10-29 | — | — | US | disclosed |
| US-7582661-B2 | Aryl sulfonamides | CHEMOCENTRYX, INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-20090163498-A1 | Aryl Sulfonamides | CHEMOCENTRYX, INC. (US) | 2009-06-25 | — | — | US | disclosed |
| US-20090118307-A1 | Aryl Sulfonamides | CHEMOCENTRYX, INC. (US) | 2009-05-07 | — | — | US | disclosed |
| US-20080293717-A1 | ARYL SULFONAMIDES | CHEMOCENTRYX, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| US-7420055-B2 | Antagonists of the chemokine receptor 9 (CCR9); inhibit TECK ligand; antiinflammatory agents and immunoregulators; inflammatory bowel disease; (2-phenylsulfonamidophenyl)-pyridinyl-methanones; N-[4-chloro-2(pyridine4-carbonyl)-phenyl]4-morpholin-4-yl-benzenesulfonamide | CHEMOCENTRYX, INC. (US) | 2008-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118307-A1 | Aryl Sulfonamides | CCR9, CCR1, CCR2 | CCR9 1/4885CCR2 3/4885LMNA 4484/4885 |
| US-20090270616-A1 | ARYL SULFONAMIDES | CCR9, CCR1, CCR2 | CCR9 1/4885CCR2 3/4885LMNA 4484/4885 |
| US-20120014997-A1 | ARYL SULFONAMIDES | CCR9, CCR1, CCR2 | CCR9 1/4885CCR2 3/4885LMNA 4484/4885 |
| US-20110021523-A1 | ARYL SULFONAMIDES | CCR9, CCR1, CCR2 | CCR9 1/4885CCR2 3/4885LMNA 4484/4885 |
| US-20150080351-A1 | ARYL SULFONAMIDES | CCR9, CCR1, CCR2 | CCR9 1/4885CCR2 3/4885LMNA 4484/4885 |
| US-20090163498-A1 | Aryl Sulfonamides | CCR9, CCR1, CCR2 | CCR9 1/4885CCR2 3/4885LMNA 4484/4885 |
| US-20080293717-A1 | ARYL SULFONAMIDES | CCR9, CCR1, CCR2 | CCR9 1/4885CCR2 3/4885LMNA 4484/4885 |
| US-20130267492-A1 | ARYL SULFONAMIDES | CCR9, CCR1, CCR2 | CCR9 1/4885CCR2 3/4885LMNA 4484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.