Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 10/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21677311 | 0.90 | NLRP3 (0.60) | NLRP3KDM4EKCNH2HSD17B10 | |
| SCHEMBL21677359 | 0.90 | NLRP3 (0.61) | NLRP3KCNH2 | |
| SCHEMBL21677364 | 0.88 | NLRP3 (0.52) | TP53NLRP3THRBKCNH2 | |
| SCHEMBL21677397 | 0.84 | HSD17B10 (0.60) | TP53NLRP3THRBKDM4ETSHR | |
| SCHEMBL25362163 | 0.84 | KDM4E (0.45) | TP53NLRP3THRBKDM4EKCNH2 | |
| SCHEMBL21677277 | 0.83 | KDM4E (0.47) | NLRP3KDM4EKCNH2HSD17B10 | |
| SCHEMBL21677399 | 0.82 | NLRP3 (0.53) | NLRP3KDM4EKCNH2 | |
| SCHEMBL21677367 | 0.81 | NLRP3 (0.57) | TP53NLRP3THRBKDM4EKCNH2 | |
| SCHEMBL21632198 | 0.80 | NLRP3 (0.71) | TP53NLRP3THRBKCNH2 | |
| SCHEMBL30455823 | 0.80 | NLRP3 (0.55) | TP53NLRP3THRBKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12168012-B2 | NLRP3 inflammasome inhibitors | NOVARTIS AG (CH) | 2024-12-17 | — | — | US | disclosed |
| EP-3827008-B1 | NLRP3 INFLAMMASOME INHIBITORS | NOVARTIS AG (CH) | 2024-07-31 | — | — | EP | disclosed |
| US-20210308140-A1 | NLRP3 INFLAMMASOME INHIBITORS | NOVARTIS AG (CH) | 2021-10-07 | — | — | US | disclosed |
| US-20210308140-A1 | NLRP3 INFLAMMASOME INHIBITORS | NOVARTIS AG (CH) | 2021-10-07 | — | — | US | disclosed |
| WO-2020021447-A1 | NLRP3 INFLAMMASOME INHIBITORS | NOVARTIS AG (CH) | 2020-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12168012-B2 | NLRP3 inflammasome inhibitors | NLRP3, NLRP1, NOD1 | TP53 1469/4885NLRP3 1/4885THRB 1672/4885 |
| US-20210308140-A1 | NLRP3 INFLAMMASOME INHIBITORS | NLRP3, NLRP1, NOD1 | TP53 1466/4885NLRP3 1/4885THRB 1623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.