Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 4/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA7 | P43166 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2340792 | 0.92 | HCAR2 (0.53) | AKR1B1AKR1B10HCAR2IDO1CA12 | |
| SCHEMBL78103 | 0.92 | HCAR2 (0.53) | AKR1B1AKR1B10HCAR2IDO1CA12 | |
| SCHEMBL21678700 | 0.87 | MAPT (0.52) | AKR1B1AKR1B10HCAR2IDO1CA12 | |
| SCHEMBL21678780 | 0.85 | HCAR2 (0.65) | AKR1B1AKR1B10HCAR2IDO1CA12 | |
| SCHEMBL78104 | 0.85 | HCAR2 (0.65) | AKR1B1AKR1B10HCAR2IDO1CA12 | |
| SCHEMBL5176891 | 0.85 | IDO1 (0.46) | AKR1B1AKR1B10HCAR2IDO1CA12 | |
| SCHEMBL21678750 | 0.84 | APP (0.50) | AKR1B1AKR1B10HCAR2IDO1ALDH1A1 | |
| SCHEMBL31003061 | 0.84 | HCAR2 (0.46) | HCAR2MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL21678777 | 0.83 | AKR1B1 (0.48) | AKR1B1AKR1B10HCAR2IDO1CA12 | |
| SCHEMBL28585290 | 0.83 | IDO1 (0.43) | AKR1B1AKR1B10IDO1CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11866401-B2 | Salicyl fumarate derivative and its application in the treatment of Parkinson's disease and other neurodegenerative diseases | CHONGQING NEUROPARK BIOSCIENCE CO., LTD. (CN) | 2024-01-09 | — | — | US | claimed |
| US-20210179533-A1 | SALICYL FUMARATE DERIVATIVE AND ITS APPLICATION IN THE TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | CHONGQING NEUROPARK BIOSCIENCE CO., LTD. (CN) | 2021-06-17 | — | — | US | claimed |
| EP-3611157-A1 | SALICYLIC ACID-BASED FUMARATE DERIVATIVE AND USE IN TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | Chongqing Neuropark Bioscience Co., Ltd. (CN) | 2020-02-19 | — | — | EP | claimed |
| US-20200048182-A1 | A SALICYL FUMARATE DERIVATIVE AND ITS APPLICATION IN THE TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | CHONGQING NEUROPARK BIOSCIENCE CO., LTD. (CN) | 2020-02-13 | — | — | US | claimed |
| US-11866401-B2 | Salicyl fumarate derivative and its application in the treatment of Parkinson's disease and other neurodegenerative diseases | CHONGQING NEUROPARK BIOSCIENCE CO., LTD. (CN) | 2024-01-09 | — | — | US | disclosed |
| US-20210179533-A1 | SALICYL FUMARATE DERIVATIVE AND ITS APPLICATION IN THE TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | CHONGQING NEUROPARK BIOSCIENCE CO., LTD. (CN) | 2021-06-17 | — | — | US | disclosed |
| EP-3611157-A1 | SALICYLIC ACID-BASED FUMARATE DERIVATIVE AND USE IN TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | Chongqing Neuropark Bioscience Co., Ltd. (CN) | 2020-02-19 | — | — | EP | disclosed |
| US-20200048182-A1 | A SALICYL FUMARATE DERIVATIVE AND ITS APPLICATION IN THE TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | CHONGQING NEUROPARK BIOSCIENCE CO., LTD. (CN) | 2020-02-13 | — | — | US | disclosed |
| CN-106946701-A | Salicylic acid-based fumarate derivative and application thereof in treating Parkinson's disease and other neurodegenerative diseases | 杨立川 | 2017-07-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179533-A1 | SALICYL FUMARATE DERIVATIVE AND ITS APPLICATION IN THE TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | FH, SUCNR1, SDHB | AKR1B1 450/4885AKR1B10 532/4885HCAR2 61/4885 |
| US-20200048182-A1 | A SALICYL FUMARATE DERIVATIVE AND ITS APPLICATION IN THE TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | FH, SUCNR1, SDHB | AKR1B1 361/4885AKR1B10 429/4885HCAR2 75/4885 |
| US-11866401-B2 | Salicyl fumarate derivative and its application in the treatment of Parkinson's disease and other neurodegenerative diseases | FH, SUCNR1, SDHB | AKR1B1 483/4885AKR1B10 549/4885HCAR2 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.