SCHEMBL21679892

SCHEMBL21679892

O=C(NCC1CN(C(=O)c2ccccc2)CCO1)C1CNC1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.48
CHRNB4 P30926 2/20 0.48
CHRNA3 P32297 2/20 0.48
CHRNA7 P36544 2/20 0.48
CHRNA4 P43681 2/20 0.48
POLB P06746 1/20 0.47
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HPGD P15428 2/20 0.43
MAPT P10636 1/20 0.43
SIGMAR1 Q99720 1/20 0.42
TSHR P16473 2/20 0.41
LMNA P02545 2/20 0.41
HTR1A P08908 2/20 0.41
HTR1B P28222 2/20 0.41
HTR2A P28223 2/20 0.41
HTR2C P28335 2/20 0.41
HTR2B P41595 2/20 0.41
GAA P10253 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL21641212 0.99 CHRNB2 (0.47) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
Hydrochloric Acid SCHEMBL21641334 0.78 DRD4 (0.54) POLB
Hydrochloric Acid SCHEMBL21640858 0.78 TSHR (0.42) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL29086066 0.77 TSHR (0.39) POLBRAB9ASMN1; SMN2HPGDTSHR
Trifluoroacetic Acid SCHEMBL21639862 0.76 TSHR (0.37) POLBRAB9ASMN1; SMN2HPGDMAPT
SCHEMBL12331041 0.73 HPGD (0.53) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
Hydrochloric Acid SCHEMBL21639817 0.72 TSHR (0.46) HPGDTSHRGAA
SCHEMBL4144028 0.71 PKM (0.54) POLBRAB9AHPGDTSHR
SCHEMBL27578096 0.71 HPGD (0.54) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL14753023 0.71 HPGD (0.61) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3604305-A1 NOVEL PYRIDONE CARBOXYLIC ACID DERIVATIVE OR SALT THEREOF Wakunaga Pharmaceutical Co., Ltd. (JP) 2020-02-05 EP disclosed